Antar Annukka A R, Peluso Michael J
Johns Hopkins University, Baltimore, Maryland, USA.
University of California San Francisco, San Francisco, USA.
Top Antivir Med. 2024 Aug 12;32(4):523-541.
Studies of acute and post-acute COVID-19, including their biology, prevention, and treatment, were presented at the 2024 Conference on Retroviruses and Opportunistic Infections. Numerous studies reported on the impact of hybrid immunity (ie, from a combination of prior infection and vaccination) on the natural history, pathogenesis, and outcomes of infection with modern SARS-CoV-2 variants. Several studies demonstrated the continued benefit of SARS-CoV-2 vaccination and the effect of treatment, particularly in the setting of severe disease. New data regarding persistent RNA shedding in immunocompromised populations were presented, demonstrating the potential challenges that this phenomenon poses with regard to viral evolution. In addition, there was a continued focus\ on post-acute sequelae of SARS-CoV-2 including its clinical manifestations and potential underlying biology. These and other studies are summarized here.
关于急性和急性后新冠病毒感染（包括其生物学特性、预防和治疗）的研究在2024年逆转录病毒与机会性感染会议上进行了展示。众多研究报告了混合免疫（即既往感染和疫苗接种相结合）对感染现代新冠病毒变异株的自然史、发病机制和感染结局的影响。多项研究证明了新冠病毒疫苗接种的持续益处以及治疗效果，尤其是在重症疾病情况下。会上展示了关于免疫功能低下人群中持续RNA脱落的新数据，证明了这一现象在病毒进化方面带来的潜在挑战。此外，人们继续关注新冠病毒的急性后后遗症，包括其临床表现和潜在的生物学基础。以下总结了这些及其他研究。
