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Dynamic allostery: a novel mechanism regulating autocrine and paracrine TGF-β signalling.

作者信息

Ungefroren Hendrik, Marquardt Jens Uwe

机构信息

First Department of Medicine, University Hospital Schleswig-Holstein (UKSH), Campus Lübeck, Lübeck, Germany.

Clinic of Surgery, University Hospital Schleswig-Holstein (UKSH), Campus Lübeck, Lübeck, Germany.

出版信息

Signal Transduct Target Ther. 2025 Jan 3;10(1):3. doi: 10.1038/s41392-024-02099-2.

DOI:10.1038/s41392-024-02099-2
PMID:39746900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11696875/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a722/11696875/6e39f6c42df9/41392_2024_2099_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a722/11696875/6e39f6c42df9/41392_2024_2099_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a722/11696875/6e39f6c42df9/41392_2024_2099_Fig1_HTML.jpg

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本文引用的文献

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Cell. 2024 Oct 31;187(22):6200-6219.e23. doi: 10.1016/j.cell.2024.08.036. Epub 2024 Sep 16.
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Autocrine TGFβ1 Opposes Exogenous TGFβ1-Induced Cell Migration and Growth Arrest through Sustainment of a Feed-Forward Loop Involving MEK-ERK Signaling.自分泌转化生长因子β1通过维持涉及MEK-ERK信号传导的前馈环来对抗外源性转化生长因子β1诱导的细胞迁移和生长停滞。
Cancers (Basel). 2021 Mar 17;13(6):1357. doi: 10.3390/cancers13061357.
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Targeting TGFβ signal transduction for cancer therapy.
针对 TGFβ 信号转导的癌症治疗。
Signal Transduct Target Ther. 2021 Jan 8;6(1):8. doi: 10.1038/s41392-020-00436-9.
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The Intimate Relationship Among EMT, MET and TME: A T(ransdifferentiation) E(nhancing) M(ix) to Be Exploited for Therapeutic Purposes.上皮-间质转化（EMT）、间质-上皮转化（MET）与肿瘤微环境（TME）之间的密切关系：一种用于治疗目的的可利用的转分化增强混合物（TEM）
Cancers (Basel). 2020 Dec 7;12(12):3674. doi: 10.3390/cancers12123674.
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FEBS J. 2013 Aug;280(16):3822-39. doi: 10.1111/febs.12377. Epub 2013 Jul 5.