Luo Nan, Lu Bing-Qiang, Deng Yu-Wei, Zeng Hua, Zhang Yu, Zhan Jing-Yu, Xu Xiao-Chen, Cao Gui-Zhi, Wen Jin, Zhang Zhiyuan, Feng Xi-Ping, Jiang Xinquan, Chen Feng, Chen Xi
Department of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
College of Stomatology, Shanghai Jiao Tong University, Shanghai, PR China.
Nat Commun. 2025 Jan 2;16(1):58. doi: 10.1038/s41467-024-54785-y.
Remineralization is a common strategy for the repair of early demineralized tooth enamels, but the harsh dynamic oral environment often hampers its efficacy. Rapid remineralization is expected to address this challenge, however, the stabilizers of remineralization materials often resist their transformation required for repair. Here, by dissolving the ions of calcium and phosphate in glycerol-dominant solvents, we obtain the calcium phosphate clusters (1-2 nm), which are stabilized by glycerol (with high viscosity and affinity to clusters), but can perform a fast enamel repair via the water-triggered transformation in both static and dynamic environments. Upon the in vitro and in vivo (female Sprague-Dawley rats) studies, the clusters swiftly enter the nano-/micro-sized enamel defect sites, then form a compact hydroxyapatite repair layer within a short time (30 min, much faster than the conventional materials), and significantly recovers mechanical properties. This material is promising for large-scale preparation and applications in dental remineralization.
再矿化是修复早期脱矿牙釉质的常用策略，但恶劣的动态口腔环境常常阻碍其效果。快速再矿化有望应对这一挑战，然而，再矿化材料的稳定剂往往会阻碍修复所需的转变。在此，通过将钙和磷酸盐离子溶解在以甘油为主的溶剂中，我们获得了磷酸钙簇（1-2纳米），其由甘油稳定（甘油具有高粘度且与簇具有亲和力），但可通过在静态和动态环境中由水引发的转变实现快速牙釉质修复。经过体外和体内（雌性斯普拉格-道利大鼠）研究，这些簇能迅速进入纳米/微米级牙釉质缺损部位，然后在短时间内（30分钟，比传统材料快得多）形成致密的羟基磷灰石修复层，并显著恢复机械性能。这种材料有望大规模制备并应用于牙齿再矿化。
