Xin Xuan-Ying, Zhou Jing, Liu Gao-Ge, Zhang Mei-Yu, Li Xiang-Zi, Wang Yan
College of Agriculture, Yabian University, Yanji, 133002, China.
Engineering Research Center of North-East Cold Region Beef Cattle Science & Technology Innovation, Ministry of Education, Department of Animal Science, Yanbian University, Yanji, 133002, China.
NPJ Sci Food. 2025 Jan 2;9(1):1. doi: 10.1038/s41538-024-00367-7.
To investigate the anti-inflammatory effects of collagen peptides, collagen peptides from cod skin were prepared to assess their in vitro anti-inflammatory effects and in vivo efficacy against ulcerative colitis. The results show that collagen peptides demonstrated anti-inflammatory effects by inhibiting the secretion of pro-inflammatory cytokines and reducing oxidative stress in vitro. In vivo, collagen peptides significantly reduced colonic tissue damage, modulated serum cytokine balance, increased the expression of tight junction proteins ZO-1, Occludin, and Claudin-1 in colon tissue, enhanced the abundance of beneficial bacteria while reducing harmful bacteria, and restored microbial balance. In addition, collagen peptides ameliorated colitis in vivo by inhibiting the phosphorylation of NF-κB p65, IκBα and p38 MAPK in the NF-κB/MAPK signaling pathway. Based on these findings, collagen peptides could serve as potential therapeutic agents for managing ulcerative colitis.
为研究胶原蛋白肽的抗炎作用，制备了来自鳕鱼皮的胶原蛋白肽，以评估其体外抗炎作用及对溃疡性结肠炎的体内疗效。结果表明，胶原蛋白肽通过在体外抑制促炎细胞因子的分泌和降低氧化应激来发挥抗炎作用。在体内，胶原蛋白肽显著减轻结肠组织损伤，调节血清细胞因子平衡，增加结肠组织中紧密连接蛋白ZO-1、闭合蛋白和Claudin-1的表达，增加有益菌数量同时减少有害菌，恢复微生物平衡。此外，胶原蛋白肽通过抑制NF-κB/MAPK信号通路中NF-κB p65、IκBα和p38 MAPK的磷酸化在体内改善结肠炎。基于这些发现，胶原蛋白肽可作为治疗溃疡性结肠炎的潜在治疗剂。
