Department of Rheumatology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China.
Jiangsu Province Hospital of Chinese medicine, Nanjing, 210029, China.
Int Orthop. 2023 Aug;47(8):1895-1919. doi: 10.1007/s00264-023-05847-1. Epub 2023 Jun 9.
Apoptosis is an important physiological process, making a great difference to development and tissue homeostasis. Osteoarthritis (OA) is a chronic joint disease characterized by degeneration and destruction of articular cartilage and bone hyperplasia. This purpose of this study is to provide an updated review of the role of apoptosis in the pathogenesis of osteoarthritis.
A comprehensive review of the literature on osteoarthritis and apoptosis was performed, which mainly focused on the regulatory factors and signaling pathways associated with chondrocyte apoptosis in osteoarthritis and other pathogenic mechanisms involved in chondrocyte apoptosis.
Inflammatory mediators such as reactive oxygen species (ROS), nitric oxide (NO), IL-1β, tumor necrosis factor-α (TNF-α), and Fas are closely related to chondrocyte apoptosis. NF-κB signaling pathway, Wnt signaling pathway, and Notch signaling pathway activate proteins and gene targets that promote or inhibit the progression of osteoarthritis disease, including chondrocyte apoptosis and ECM degradation. Long non-coding RNAs (LncRNAs) and microRNAs (microRNAs) have gradually replaced single and localized research methods and become the main research approaches. In addition, the relationship between cellular senescence, autophagy, and apoptosis was also briefly explained.
This review offers a better molecular delineation of apoptotic processes that may help in designing new therapeutic options for OA treatment.
细胞凋亡是一种重要的生理过程，对发育和组织稳态有很大影响。骨关节炎（OA）是一种慢性关节疾病，其特征为关节软骨退化和破坏以及骨质增生。本研究旨在提供细胞凋亡在骨关节炎发病机制中的作用的最新综述。
对骨关节炎和细胞凋亡的文献进行了全面综述，主要集中在与 OA 中软骨细胞凋亡相关的调节因子和信号通路以及涉及软骨细胞凋亡的其他致病机制上。
炎性介质如活性氧（ROS）、一氧化氮（NO）、IL-1β、肿瘤坏死因子-α（TNF-α）和 Fas 与软骨细胞凋亡密切相关。NF-κB 信号通路、Wnt 信号通路和 Notch 信号通路激活蛋白和基因靶点，促进或抑制骨关节炎疾病的进展，包括软骨细胞凋亡和 ECM 降解。长链非编码 RNA（lncRNA）和 microRNA（miRNA）逐渐取代了单一和局部的研究方法，成为主要的研究方法。此外，细胞衰老、自噬和细胞凋亡之间的关系也进行了简要说明。
本综述为凋亡过程提供了更好的分子描述，可能有助于设计 OA 治疗的新治疗选择。
