Kunimatsu-Sanuki Shiho, Fukuchi Takeo, Takahashi Masayo, Mizota Atsushi, Inoue Kenji
Nishikasai Inouye Eye Hospital, Tokyo, Japan.
Nishikasai Inouye Eye Hospital, 3-12-14 Nishikasai, Edogawa-Ku, Tokyo, 134-0088, Japan.
Sci Rep. 2025 Jan 2;15(1):423. doi: 10.1038/s41598-024-84465-2.
We investigated subjective symptoms during driving in 227 glaucoma patients at a driving assessment clinic. Patients underwent testing with the Humphrey Field Analyzer 24-2 (HFA 24-2) and a driving simulator (DS) with eye tracking. Patients reported whether they experienced symptoms during daily driving, such as fear or difficulty seeing under certain conditions. The integrated visual field (IVF) was calculated from HFA 24-2 data. The number of collisions in DS scenarios and eye movements during DS testing was recorded, and factors related to the presence of subjective symptom during driving were analyzed using multivariate logistic regression, with subjective symptoms as the dependent variable. Overall, 145 patients (63.9%) did not report subjective symptoms during driving. Rates of these symptoms were 22.9%, 36.6%, and 41.7% for mild, moderate, and severe glaucoma, respectively (P = 0.030). Patients with symptoms had worse better-eye mean deviation (MD) (P = 0.012) and lower IVF sensitivity in the superior hemifield (P < 0.002). Logistic regression revealed a significant association between symptoms and decreased superior IVF sensitivity from 0° to 12° (P = 0.0029; OR: 1.07). Our study highlights that many glaucoma patients, even with severe disease, may not be aware of visual symptoms during driving, though superior IVF mean sensitivity contributed to subjective symptoms during driving.
我们在一家驾驶评估诊所对227名青光眼患者在驾驶过程中的主观症状进行了调查。患者接受了Humphrey视野分析仪24-2（HFA 24-2）和带有眼动追踪功能的驾驶模拟器（DS）测试。患者报告他们在日常驾驶中是否经历过症状，例如在某些情况下感到恐惧或视物困难。综合视野（IVF）由HFA 24-2数据计算得出。记录了DS场景中的碰撞次数和DS测试期间的眼动情况，并以主观症状作为因变量，使用多因素逻辑回归分析了与驾驶过程中主观症状存在相关的因素。总体而言，145名患者（63.9%）在驾驶过程中未报告主观症状。轻度、中度和重度青光眼患者出现这些症状的比例分别为22.9%、36.6%和41.7%（P = 0.030）。有症状的患者较好眼的平均偏差（MD）更差（P = 0.012），上半视野的IVF敏感性更低（P < 0.002）。逻辑回归显示症状与0°至12°上半视野IVF敏感性降低之间存在显著关联（P = 0.0029；OR：1.07）。我们的研究强调，许多青光眼患者即使患有严重疾病，在驾驶过程中可能也未意识到视觉症状，尽管上半视野IVF平均敏感性会导致驾驶过程中的主观症状。
