Kimura Naoyuki, Machii Yojiro, Hori Daijiro, Mieno Makiko, Eguchi Naoki, Shiraishi Manabu, Yamaguchi Atsushi, Matsumoto Kenji, Tanaka Masashi
Division of Cardiovascular Surgery, Department of Surgery, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, 329-0498, Japan.
Department of Cardiovascular Surgery, Nihon University Hospital, Itabashi-ku, Tokyo, Japan.
Sci Rep. 2025 Jan 2;15(1):475. doi: 10.1038/s41598-024-84117-5.
We investigated the influence of false lumen (FL) status on the systemic inflammatory response triggered by acute aortic dissection (AAD) using cytokine profiling. The study included 44 patients with AAD. Patients were divided between those with a thrombosed FL (Group T, n = 21) and those with a non-thrombosed FL (Group P, n = 23). On-admission serum concentrations of 29 cytokines were compared between unmatched and propensity-score matched (n = 10 pairs) FL groups and a control group (non-ruptured thoracic aortic aneurysm, Group C, n = 20). Unmatched analysis showed 12 cytokines differed between groups and fell into three categories: Category A (increased expression in both FL groups: IL-6, IL-10, IL-15, G-CSF); Category B (increased expression only in Group P: IL-1Ra, IL-1β, IL-8, IL-12p70, GM-CSF); and Category C (others: IP-10, VEGF-A, eotaxin). The increases in Category A and Category B cytokines in Group T were attenuated, but not significantly, compared to their increases in Group P. Propensity-score matching analysis revealed a similar expression pattern with respect to all four Category A cytokines, four Category B cytokines (IL-1β, IL-1Ra, IL-12p70, and GM-CSF), and two Category C cytokines (IP-10 and VEGF-A). A robust inflammatory response occurs in patients with AAD, but the response is attenuated when the FL is thrombosed.
我们使用细胞因子谱分析研究了假腔（FL）状态对急性主动脉夹层（AAD）引发的全身炎症反应的影响。该研究纳入了44例AAD患者。患者被分为假腔血栓形成组（T组，n = 21）和假腔未血栓形成组（P组，n = 23）。比较了未匹配和倾向评分匹配（n = 10对）的FL组与对照组（非破裂胸主动脉瘤，C组，n = 20）入院时29种细胞因子的血清浓度。未匹配分析显示，12种细胞因子在各组之间存在差异，可分为三类：A类（在两个FL组中表达均增加：IL-6、IL-10、IL-15、G-CSF）；B类（仅在P组中表达增加：IL-1Ra、IL-1β、IL-8、IL-12p70、GM-CSF）；C类（其他：IP-10、VEGF-A、嗜酸性粒细胞趋化因子）。与P组相比，T组中A类和B类细胞因子的增加有所减弱，但不显著。倾向评分匹配分析显示，所有四种A类细胞因子、四种B类细胞因子（IL-1β、IL-1Ra、IL-12p70和GM-CSF）以及两种C类细胞因子（IP-10和VEGF-A）的表达模式相似。AAD患者会发生强烈的炎症反应，但当假腔血栓形成时，炎症反应会减弱。
