St epniewski M, Smoleński O, Kopeć J, Kuźniewski M
Nephron. 1985;39(3):189-93. doi: 10.1159/000183370.
Effect of hemodialysis on phenylalanine distribution between the intracellular water of erythrocytes and the plasma obtained from patients with end-stage kidney was studied by fluorimetric measurements of phenylalanine concentration according to the method of Mc Caman and Robins. The measurements were performed twice: before and after 4 h of hemodialysis. It was found that the nondialyzed patients with end-stage kidney had higher than normal phenylalanine concentrations both in plasma and in the intracellular water of erythrocytes. Hemodialysis brought about a decrease in plasma phenylalanine level without influencing the erythrocyte concentration of the studied amino acid and without altering the function of the erythrocyte cell membrane, as far as the phenylalanine transport was concerned.
采用麦卡曼和罗宾斯的方法，通过荧光法测量苯丙氨酸浓度，研究了血液透析对终末期肾病患者红细胞细胞内水和血浆中苯丙氨酸分布的影响。测量在血液透析前和透析4小时后各进行一次。结果发现，未透析的终末期肾病患者血浆和红细胞细胞内水中的苯丙氨酸浓度均高于正常水平。就苯丙氨酸转运而言，血液透析使血浆苯丙氨酸水平降低，而不影响所研究氨基酸在红细胞中的浓度，也不改变红细胞细胞膜的功能。
