DeBari V A, Bennun A
Clin Biochem. 1982 Aug;15(4):219-21. doi: 10.1016/s0009-9120(82)90160-6.
We have studied the intracellular levels of cyclic GMP in the red blood cells of chronic hemodialysis patients before and after dialysis treatment and in normal subjects. Cyclic GMP is present at levels (mean +/- 1SD) of 19.6 +/- 4.7 and 18.4 +/- 5.8 nM/L before and after treatment, respectively. The levels in normal subjects are 3.6 +/- 0.9. The uptake of cyclic GMP was also studied and the data demonstrate that the red blood cell is slightly permeable to cyclic GMP, suggesting that cyclic GMP uptake could substitute for guanylate cyclase activity in the human erythrocyte.
我们研究了慢性血液透析患者透析治疗前后及正常受试者红细胞内的环磷酸鸟苷（cGMP）水平。治疗前和治疗后，cGMP水平（均值±1标准差）分别为19.6±4.7和18.4±5.8 nM/L。正常受试者的水平为3.6±0.9。我们还研究了cGMP的摄取情况，数据表明红细胞对cGMP有轻微通透性，这表明cGMP摄取可能替代人红细胞中的鸟苷酸环化酶活性。
