Petrovic Masa, Salovic Bojana, Tomic Ana, Jesic-Petrovic Tanja, Matejic Aleksandar, Radovic Ivana, Babic Silvana, Korugic Aleksa, Jelovac Drago, Mikovic Nikola, Jakovljevic Sasa, Pelemis Svetislav, Dimitrijevic Milovan, Milovanovic Jovica, Jotic Ana, Trivic Aleksandar, Dimitrijevic Ana, Bulatovic Sulin, Dudvarski Zoran, Soldatovic Ivan, Ilic-Zivojinovic Jelena
Institute for Cardiovascular Diseases "Dedinje", Belgrade, Serbia.
Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Sci Rep. 2025 Jan 2;15(1):298. doi: 10.1038/s41598-024-83246-1.
This study aimed to translate and validate the Functional Assessment of Cancer Therapy - Head & Neck (FACT-HN) in a Serbian-speaking population, assessing its psychometric properties and utility in evaluating the quality of life in head and neck cancer patients. The research focuses on determining the translated questionnaire's reliability, validity, and cultural relevance. A total of 106 Serbian-speaking head and neck cancer patients completed the translated FACT-HN, along with other validated instruments, including the EORTC QLQ-C30, EORTC QLQ-HN43, CES-D, and GAD-7. The translation followed a standard internationally accepted procedure. Psychometric analyses were conducted using confirmatory and exploratory factor analysis, Pearson correlations, and reliability measures such as Cronbach's alpha and intraclass correlation coefficients. The Serbian version of the FACT-HN showed excellent internal consistency across all subscales, with Cronbach's alpha ranging from 0.70 to 0.89. Confirmatory factor analysis confirmed the five-factor structure. Strong correlations were observed between the FACT-HN and other validated QoL measures, particularly with the EORTC QLQ-C30 and EORTC QLQ-HN43. Convergent validity was satisfactory for all components except the Social Well-Being component. The Serbian version of the FACT-HN is a valid and reliable tool for assessing the quality of life in head and neck cancer patients. It provides a comprehensive assessment of physical, social, emotional, and functional well-being, making it valuable for clinical and research applications in Serbian-speaking populations. Further research is needed to assess its sensitivity to longitudinal treatment-related changes.
本研究旨在对塞尔维亚语人群进行癌症治疗功能评估-头颈部（FACT-HN）量表的翻译与验证，评估其心理测量学特性以及在评估头颈部癌症患者生活质量方面的效用。该研究聚焦于确定翻译后问卷的信度、效度和文化相关性。共有106名讲塞尔维亚语的头颈部癌症患者完成了翻译后的FACT-HN量表，以及其他经过验证的工具，包括欧洲癌症研究与治疗组织核心生活质量问卷（EORTC QLQ-C30）、欧洲癌症研究与治疗组织头颈部癌症特异性问卷（EORTC QLQ-HN43）、流调中心抑郁量表（CES-D）和广泛性焦虑障碍量表（GAD-7）。翻译遵循国际认可的标准程序。使用验证性和探索性因子分析、皮尔逊相关性分析以及诸如克朗巴哈系数和组内相关系数等信度测量方法进行心理测量学分析。FACT-HN量表的塞尔维亚语版本在所有子量表中均显示出出色的内部一致性，克朗巴哈系数范围为0.70至0.89。验证性因子分析证实了五因子结构。在FACT-HN量表与其他经过验证的生活质量测量工具之间观察到强相关性，尤其是与EORTC QLQ-C30和EORTC QLQ-HN43。除社会幸福感分量表外，所有分量表的收敛效度均令人满意。FACT-HN量表的塞尔维亚语版本是评估头颈部癌症患者生活质量的有效且可靠的工具。它对身体、社会、情感和功能幸福感进行了全面评估，对讲塞尔维亚语人群的临床和研究应用具有重要价值。需要进一步研究以评估其对与治疗相关的纵向变化的敏感性。
