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L-天冬氨酸功能化磁性纳米粒子：作为一种新型可磁重复使用的酸碱双功能催化剂用于合成苯并[b]吡喃和吡喃并[3,2-c]色烯衍生物。

L-Aspartic acid-functionalized magnetic nanoparticles: as a new magnetically reusable bifunctional acid-base catalysts for the synthesis of benzo[b]pyran and pyrano[3,2-c] chromene derivatives.

作者信息

Amiri-Zirtol Leila, Mostashfi Hanieh, Sabet Razieh, Karimi Zahra, Ranjbar-Karimi Reza

机构信息

Pharmaceutical Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Department of Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Sci Rep. 2025 Jan 2;15(1):248. doi: 10.1038/s41598-024-71901-6.

DOI:10.1038/s41598-024-71901-6
PMID:39747901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11697017/
Abstract

"Green chemistry" describes the development of new technologies that reduce or eliminate the need for hazardous compounds or the production of them. In order to accomplish this goal, we have developed a new magnetic recyclable biocatalyst in this study by successfully applying aspartic acid to magnetic nanoparticles. Aspartic acid's molecular makeup made it possible for it to stabilize on magnetic nanoparticles using a straightforward method. We characterized the synthesized catalyst using microscopic and spectroscopic techniques such as Fourier transform infrared (FT-IR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM), Energy-dispersive X-ray spectroscopy (EDS), vibrating sample magnetometer (VSM) and transmission electron microscopy (TEM). The catalytic activity of this organocatalyst was evaluated for the synthesis of benzo[b]pyran and pyrano[3,2-c] chromene derivatives, exhibiting excellent efficiency. This protocol offers several benefits, such as using a low-cost biocatalyst, nontoxicity, high product yield, easy separation, short reaction times, catalyst reusability, and HO/EtOH solvent. In summary, our research indicates a feasible approach towards developing a novel magnetic biocatalyst suitable for application in organic synthesis.

摘要

“绿色化学”描述了新技术的发展，这些技术减少或消除了对有害化合物的需求或其生产。为了实现这一目标，我们在本研究中通过将天冬氨酸成功应用于磁性纳米颗粒，开发了一种新型的可磁回收生物催化剂。天冬氨酸的分子组成使其能够通过一种简单的方法稳定在磁性纳米颗粒上。我们使用傅里叶变换红外光谱（FT-IR）、X射线衍射（XRD）、场发射扫描电子显微镜（FE-SEM）、能量色散X射线光谱（EDS）、振动样品磁强计（VSM）和透射电子显微镜（TEM）等显微镜和光谱技术对合成的催化剂进行了表征。评估了该有机催化剂在合成苯并[b]吡喃和吡喃并[3,2-c]色烯衍生物方面的催化活性，显示出优异的效率。该方案具有诸多优点，例如使用低成本生物催化剂、无毒、产品收率高、易于分离、反应时间短、催化剂可重复使用以及使用HO/EtOH溶剂。总之，我们的研究表明了一种开发适用于有机合成的新型磁性生物催化剂的可行方法。

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