Ng Kuan Chong, Chueh Jeff Shih-Chieh, Chang Shang-Jen
Department of Urology, National Taiwan University Hospital, No. 7, Zhongshan S. Rd., Zhongzheng Dist., Taipei, 100, Taiwan.
Sci Rep. 2025 Jan 2;15(1):235. doi: 10.1038/s41598-024-84031-w.
Patients with overactive bladder syndrome-wet (OAB-wet) experience urgency urinary incontinence, particularly urinary frequency and nocturia. Nocturnal enuresis (NE) is less addressed among OAB-wet patients. The study evaluated the prevalence of NE, lower urinary tract symptoms (LUTS), urodynamic factors, and social factors in OAB-wet patient. Over three years, adult women with urgency urinary incontinence were enrolled. A comprehensive questionnaire, including baseline characteristics, LUTS, fatigue, stress, and partner relationship was completed by the participants. NE was defined as complaint of intermittent incontinence that occurs during the main sleep period. Urodynamics was performed on every patient to assess bladder function. Of 203 OAB-wet patients (age: 64.45 years), 46.4% had NE. Patients with NE had higher scores of intermittency, slow stream, straining, hesitancy, post micturition dribble, nocturia, and stress urinary incontinence than non-NE. NE patients had a more parity numbers, diuretic, hypnotic, and prokinetic use, and smoking. NE patients more likely reported fatigue, anxiety, and distress. Urodynamic studies revealed more detrusor overactivity, detrusor underactivity, and low bladder compliance in NE patients. In conclusion, OAB-wet women with NE had more detrusor overactivity, detrusor underactivity, and a lower compliance bladder on urodynamic studies than those without NE. NE impacts the patients' life in aggravating fatigues, anxiety, and distress in OAB-wet women.
膀胱过度活动症伴尿失禁（OAB-wet）患者会经历急迫性尿失禁，尤其是尿频和夜尿症。在OAB-wet患者中，夜间遗尿（NE）较少受到关注。该研究评估了OAB-wet患者中NE的患病率、下尿路症状（LUTS）、尿动力学因素和社会因素。在三年多的时间里，招募了患有急迫性尿失禁的成年女性。参与者完成了一份综合问卷，包括基线特征、LUTS、疲劳、压力和伴侣关系。NE被定义为在主要睡眠期间出现的间歇性失禁主诉。对每位患者进行尿动力学检查以评估膀胱功能。在203名OAB-wet患者（年龄：64.45岁）中，46.4%患有NE。与无NE的患者相比，患有NE的患者在间歇性、尿流缓慢、排尿费力、排尿犹豫、排尿后滴沥、夜尿症和压力性尿失禁方面得分更高。NE患者的产次更多，使用利尿剂、催眠药和促动力药的情况更多，且吸烟。NE患者更有可能报告疲劳、焦虑和痛苦。尿动力学研究显示，NE患者的逼尿肌过度活动、逼尿肌活动不足和膀胱顺应性降低的情况更多。总之，与无NE的OAB-wet女性相比，患有NE的OAB-wet女性在尿动力学研究中逼尿肌过度活动、逼尿肌活动不足和膀胱顺应性更低。NE会加重OAB-wet女性的疲劳、焦虑和痛苦，从而影响患者的生活。
