Ponthier Laure, El Hamel Chahrazed, Coste Mazeau Perrine, Martinez Sophie, Wehbe Sarah, Froget Rachel, Yardin Catherine, Guigonis Vincent
Collection Biologique de L'Hôpital de La Mère Et de L'Enfant CB-HME (Mother and Child Biobank), University Hospital Center, 8 Avenue Dominique Larrey, Limoges, France.
Department of Pediatrics, University Hospital Center, 8 Avenue Dominique Larrey, Limoges, France.
BMC Pregnancy Childbirth. 2025 Jan 2;25(1):1. doi: 10.1186/s12884-024-07102-w.
Maternal agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AAs) have been implicated in the pathophysiology of preeclampsia, but their presence in their offsprings and their possible neonatal effects have not been specifically explored. This prospective study aimed to evaluate the presence of AT1-AAs and their potential clinical effects in neonates of AT1-AAs positive mothers.
Women with preeclampsia and their neonates were included. Blood samples were collected in order to search for AT1-AAs.
AT1-AA determination was positive in 35 out of 64 of the studied women (54.7%). Thirty one newborns from the group of AT1-AA positive women were included and 22 (71%) were AT1-AA positive. The mothers' and children's AT1-AAs titers were significantly correlated. The 33 newborns from the group of AT1-AA negative women were all negative for AT1-AAs. Regarding the clinical data of newborns (birth weight, percentile of weight, gestational age, Apgar score at five minutes, mechanical or noninvasive ventilation), no significant difference was observed between the children with or without detected AT1-AAs.
Even though AT1-AAs are detected in newborns of positive mothers during the first days of life, no specific clinical signs seem to be associated with the presence of these antibodies.
母体抗血管紧张素II 1型受体自身抗体（AT1 - AAs）与子痫前期的病理生理机制有关，但其在后代中的存在情况及其可能的新生儿效应尚未得到专门研究。这项前瞻性研究旨在评估AT1 - AAs阳性母亲的新生儿中AT1 - AAs的存在情况及其潜在临床效应。
纳入患有子痫前期的女性及其新生儿。采集血样以检测AT1 - AAs。
在所研究的64名女性中，35名（54.7%）的AT1 - AA检测呈阳性。纳入了AT1 - AA阳性女性组的31名新生儿，其中22名（71%）AT1 - AA呈阳性。母亲和孩子的AT1 - AAs滴度显著相关。AT1 - AA阴性女性组的33名新生儿的AT1 - AAs检测均为阴性。关于新生儿的临床数据（出生体重、体重百分位数、胎龄、5分钟阿氏评分、机械通气或无创通气），检测到或未检测到AT1 - AAs的儿童之间未观察到显著差异。
尽管在出生后几天内，在AT1 - AAs阳性母亲的新生儿中检测到了AT1 - AAs，但似乎没有特定临床体征与这些抗体的存在相关。
