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狼疮性肾炎中膜联蛋白A1的表达

Annexin A1 expression in Lupus Nephritis.

作者信息

Dhaffouli Fatma, Hachicha Hend, Elloumi Nesrine, Fakhfakh Raouia, Feki Sawsen, Ben Hmida Mohamed, Sellami Boudawara Tahya, Kammoun Khawla, Masmoudi Hatem

机构信息

Research Laboratory LR18/SP12 "Autoimmunity, Cancer, and Immunogenetics", Habib Bourguiba hospital, Sfax, Tunisia.

Faculty of Medicine of Sfax, Renal Pathology Laboratory LR19ES11.

出版信息

Tunis Med. 2024 Dec 5;102(12):1025-1030. doi: 10.62438/tunismed.v102i12.5005.

DOI:10.62438/tunismed.v102i12.5005
PMID:39748688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11770797/
Abstract

INTRODUCTION

Lupus nephritis (LN) is an immune complex glomerulonephritis, caused by systemic lupus erythematosus. It is associated with an increase of morbidity and mortality. In LN, the immune responses dysregulation is one of the crucial pathogenic pathways. Annexin A1 (AnxA1), as an anti-inflammatory mediator, plays a critical role in immune responses, in addition to a variety of pathological processes.

AIM

This study aimed to evaluate the AnxA1 expression in renal tissues, in order to explore its potential role in LN pathogenesis.

METHODS

AnxA1 expression was performed by immunohistochemistry staining in renal biopsies of 24 LN patients compared to 8 controls.

RESULTS

LN patient's biopsies showed an increased distribution of AnxA1 in glomeruli compared to controls (p=0.00019). When comparing AnxA1 expression in different LN classes, a high AnxA1 intensity score was positively correlated with glomerular proliferation.

CONCLUSION

Our data suggest AnxA1 as a useful marker to differentiate between severe proliferative and non severe proliferative classes of LN.

摘要

引言

狼疮性肾炎（LN）是一种由系统性红斑狼疮引起的免疫复合物性肾小球肾炎。它与发病率和死亡率的增加有关。在LN中，免疫反应失调是关键的致病途径之一。膜联蛋白A1（AnxA1）作为一种抗炎介质，除了在多种病理过程中发挥作用外，在免疫反应中也起着关键作用。

目的

本研究旨在评估AnxA1在肾组织中的表达，以探讨其在LN发病机制中的潜在作用。

方法

通过免疫组化染色对24例LN患者的肾活检组织进行AnxA1表达检测，并与8例对照进行比较。

结果

与对照组相比，LN患者的肾活检组织显示肾小球中AnxA1的分布增加（p=0.00019）。在比较不同LN类型中AnxA1的表达时，高AnxA1强度评分与肾小球增殖呈正相关。

结论

我们的数据表明AnxA1是区分LN严重增殖型和非严重增殖型的有用标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/cf5a9bba1149/capture6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/dd4692b34cfa/capture1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/0c07fd09358f/capture2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/d093f0016317/capture3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/9b17c75dfa96/capture4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/0d371b9eebc5/capture5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/cf5a9bba1149/capture6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/dd4692b34cfa/capture1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/0c07fd09358f/capture2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/d093f0016317/capture3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/9b17c75dfa96/capture4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/0d371b9eebc5/capture5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/786a/11770797/cf5a9bba1149/capture6.jpg

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本文引用的文献

1
Annexin A1 and its receptor gene polymorphisms in systemic lupus erythematosus in the Tunisian population.突尼斯人群系统性红斑狼疮中膜联蛋白A1及其受体基因多态性
Clin Rheumatol. 2022 May;41(5):1359-1369. doi: 10.1007/s10067-022-06057-7. Epub 2022 Jan 14.
2
Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes.鉴定 AnnexinA1 为 RhoA 的内源性调节剂，及其在 2 型糖尿病病理生理学和实验治疗中的作用。
Front Immunol. 2019 Mar 27;10:571. doi: 10.3389/fimmu.2019.00571. eCollection 2019.
3
Annexin A1: Uncovering the Many Talents of an Old Protein.
膜联蛋白 A1：揭示古老蛋白的多重潜能。
Int J Mol Sci. 2018 Mar 31;19(4):1045. doi: 10.3390/ijms19041045.
4
The role of the immune system in kidney disease.免疫系统在肾脏疾病中的作用。
Clin Exp Immunol. 2018 May;192(2):142-150. doi: 10.1111/cei.13119. Epub 2018 Mar 24.
5
Redefining lupus nephritis: clinical implications of pathophysiologic subtypes.重新定义狼疮肾炎：病理生理亚型的临床意义。
Nat Rev Nephrol. 2017 Aug;13(8):483-495. doi: 10.1038/nrneph.2017.85. Epub 2017 Jul 3.
6
Targeting of regulated necrosis in kidney disease.针对肾脏疾病中的程序性坏死
Nefrologia (Engl Ed). 2018 Mar-Apr;38(2):125-135. doi: 10.1016/j.nefro.2017.04.004. Epub 2017 Jun 21.
7
The Increased Expression of Toll-Like Receptor 4 in Renal and Skin Lesions in Lupus Erythematosus.狼疮性肾炎和皮肤病变中Toll样受体4表达增加
J Histochem Cytochem. 2017 Jul;65(7):389-398. doi: 10.1369/0022155417709234. Epub 2017 May 22.
8
Infiltrating CD16 Are Associated with a Reduction in Peripheral CD14CD16 Monocytes and Severe Forms of Lupus Nephritis.浸润性CD16与外周血CD14CD16单核细胞减少及重症狼疮性肾炎相关。
Autoimmune Dis. 2016;2016:9324315. doi: 10.1155/2016/9324315. Epub 2016 Dec 13.
9
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Nephron. 2017;136(4):263-267. doi: 10.1159/000447649. Epub 2016 Oct 22.
10
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J Immunol Res. 2016;2016:8239258. doi: 10.1155/2016/8239258. Epub 2016 Jan 13.