狼疮性肾炎中膜联蛋白A1的表达
Annexin A1 expression in Lupus Nephritis.
作者信息
Dhaffouli Fatma, Hachicha Hend, Elloumi Nesrine, Fakhfakh Raouia, Feki Sawsen, Ben Hmida Mohamed, Sellami Boudawara Tahya, Kammoun Khawla, Masmoudi Hatem
机构信息
Research Laboratory LR18/SP12 "Autoimmunity, Cancer, and Immunogenetics", Habib Bourguiba hospital, Sfax, Tunisia.
Faculty of Medicine of Sfax, Renal Pathology Laboratory LR19ES11.
出版信息
Tunis Med. 2024 Dec 5;102(12):1025-1030. doi: 10.62438/tunismed.v102i12.5005.
INTRODUCTION
Lupus nephritis (LN) is an immune complex glomerulonephritis, caused by systemic lupus erythematosus. It is associated with an increase of morbidity and mortality. In LN, the immune responses dysregulation is one of the crucial pathogenic pathways. Annexin A1 (AnxA1), as an anti-inflammatory mediator, plays a critical role in immune responses, in addition to a variety of pathological processes.
AIM
This study aimed to evaluate the AnxA1 expression in renal tissues, in order to explore its potential role in LN pathogenesis.
METHODS
AnxA1 expression was performed by immunohistochemistry staining in renal biopsies of 24 LN patients compared to 8 controls.
RESULTS
LN patient's biopsies showed an increased distribution of AnxA1 in glomeruli compared to controls (p=0.00019). When comparing AnxA1 expression in different LN classes, a high AnxA1 intensity score was positively correlated with glomerular proliferation.
CONCLUSION
Our data suggest AnxA1 as a useful marker to differentiate between severe proliferative and non severe proliferative classes of LN.
引言
狼疮性肾炎（LN）是一种由系统性红斑狼疮引起的免疫复合物性肾小球肾炎。它与发病率和死亡率的增加有关。在LN中，免疫反应失调是关键的致病途径之一。膜联蛋白A1（AnxA1）作为一种抗炎介质，除了在多种病理过程中发挥作用外，在免疫反应中也起着关键作用。
目的
本研究旨在评估AnxA1在肾组织中的表达，以探讨其在LN发病机制中的潜在作用。
方法
通过免疫组化染色对24例LN患者的肾活检组织进行AnxA1表达检测，并与8例对照进行比较。
结果
与对照组相比，LN患者的肾活检组织显示肾小球中AnxA1的分布增加（p=0.00019）。在比较不同LN类型中AnxA1的表达时，高AnxA1强度评分与肾小球增殖呈正相关。
结论
我们的数据表明AnxA1是区分LN严重增殖型和非严重增殖型的有用标志物。
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