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成人恶性黑色素瘤的罕见表现:诊断与治疗见解

A Rare Presentation of Malignant Melanoma in an Adult: Diagnostic and Therapeutic Insights.

作者信息

Pudota Mithun Chakraverthy, Udamala Sneha, Vallapuri Guna Sai

机构信息

General Surgery, P.E.S. Institute of Medical Sciences and Research, Kuppam, IND.

出版信息

Cureus. 2024 Dec 3;16(12):e75016. doi: 10.7759/cureus.75016. eCollection 2024 Dec.

Abstract

This case presents a rare and aggressive manifestation of malignant melanoma, initially presenting as a chest wall swelling in a young male with a history of trauma and subsequent management for hemothorax and pyothorax. The complexity of this case lies in its atypical presentation and the challenges posed in diagnosis and treatment. A 30-year-old gentleman presented to the general surgery clinic with a chief complaint of swelling on the right side of his chest, persisting for two months following a traumatic fall, which later resulted in hemothorax and prothorax required drainage and eventually ended up developing a swelling requiring further investigations. Imaging studies, including CT and contrast-enhanced CT, indicated a large heterogeneous mass with lytic destruction of the underlying rib and infiltration into adjacent structures. An incisional biopsy confirmed the diagnosis, which required a wide local excision of the tumor. Intraoperatively, the tumor was found to involve surrounding structures, necessitating extensive resection and reconstruction. After surgical removal, histopathological examination confirmed malignant melanoma with involved margins. Additional studies like immunohistochemistry and PET-CT were required to understand the comprehensive understanding of tumor and its metastasis. Malignant melanoma, though rare, should be considered in the differential diagnosis of atypical chest wall swellings, especially in patients with recent trauma and surgical interventions. This case underscores the aggressive nature and complex management of melanoma, highlighting the necessity for prompt diagnosis and comprehensive treatment strategies to improve patient outcomes.

摘要

该病例呈现出恶性黑色素瘤一种罕见且侵袭性的表现形式,最初表现为一名有创伤史的年轻男性胸壁肿胀,随后因血胸和气胸接受治疗。该病例的复杂性在于其非典型表现以及诊断和治疗中所面临的挑战。一名30岁男性到普通外科门诊就诊,主诉右侧胸部肿胀,在一次外伤性跌倒后持续了两个月,随后导致血胸,胸腔需要引流,最终出现肿胀,需要进一步检查。包括CT和增强CT在内的影像学检查显示有一个大的异质性肿块,伴有肋骨溶骨性破坏并浸润至相邻结构。切开活检确诊后,需要对肿瘤进行广泛局部切除。术中发现肿瘤累及周围结构,需要进行广泛切除和重建。手术切除后,组织病理学检查确诊为恶性黑色素瘤且切缘受累。还需要进行免疫组化和PET-CT等进一步检查以全面了解肿瘤及其转移情况。恶性黑色素瘤虽然罕见,但在非典型胸壁肿胀的鉴别诊断中应予以考虑,尤其是近期有创伤和手术干预的患者。该病例强调了黑色素瘤的侵袭性本质和复杂治疗,凸显了及时诊断和综合治疗策略以改善患者预后的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0e/11694329/962d2699974a/cureus-0016-00000075016-i01.jpg

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