Kanazawa Koichiro, Oishi Shinnosuke, Sakamoto Akihiko, Tanabe Kuniaki, Sugiyama Kazutaka, Matsumoto Akihiko, Arakawa Akari, Matsunaga Hiromi, Harada Takafumi, Kume Haruki
Department of Urology Yaizu City Hospital Yaizu Shizuoka Japan.
Department of Ophthalmology Yaizu City Hospital Yaizu Shizuoka Japan.
IJU Case Rep. 2024 Dec 6;8(1):77-80. doi: 10.1002/iju5.12819. eCollection 2025 Jan.
Choroidal metastasis from renal cell carcinoma is relatively rare and unresponsive to systemic treatment.
A man in his eighties with left renal cell carcinoma and pulmonary metastasis developed visual impairment in the left eye during primary treatment with ipilimumab and nivolumab followed by secondary treatment with cabozantinib. Consultation with an ophthalmologist revealed choroidal metastasis, which was subsequently treated with local radiotherapy (3 Gy × 10 Fr), resulting in a significant reduction in the metastatic lesions.
If visual impairment arises while treating renal cell carcinoma, it is essential to consider the possibility of intraocular metastasis. In terms of treatment, local therapies such as radiotherapy should be taken into consideration.
肾细胞癌的脉络膜转移相对罕见,且对全身治疗无反应。
一名八十多岁的男性,患有左肾细胞癌并伴有肺转移,在接受伊匹单抗和纳武单抗一线治疗后,继以卡博替尼二线治疗期间,左眼出现视力障碍。眼科会诊发现脉络膜转移,随后接受局部放疗(3 Gy×10次分割),转移病灶显著缩小。
在治疗肾细胞癌时若出现视力障碍,必须考虑眼内转移的可能性。在治疗方面,应考虑放疗等局部治疗方法。