Yim Jae-Hyuk, Kim Tae-Un, Kim Woo Jun, Bae Seulgi, Yun Sungho, Baek Su-Min, Park Jin-Kyu
Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
J Vet Sci. 2025 Jan;26(1):e3. doi: 10.4142/jvs.24246. Epub 2024 Dec 10.
Hemochromatosis is rare in domestic animals, and iron-induced myopathy has not been reported in veterinary medicine. This case is the first report of iron-overload myopathy owing to hemochromatosis in a dog.
A 9-year-old spayed female Donggyeong dog presented with severe forelimb lameness. Necropsy revealed an enlarged liver and hemorrhagic lesions in the forelimb muscle. Microscopy showed iron components accumulation in multiple organs, including the liver, forelimb skeletal muscle, spleen, lymph node, and kidney. Prussian blue staining identified iron deposits in both macrophages and parenchymal cells, indicating that the iron accumulation was acquired rather than hereditary. Furthermore, iron components were observed within muscle fibers, accompanied by severe atrophy and myositis.
Severe necrosis and mild fibrosis were observed in the liver and forelimb skeletal muscles. Based on histological analysis, we diagnosed iron overload myopathy by secondary hemochromatosis. Secondary hemochromatosis with severe muscle atrophy and myositis is very rare, and this is the first report of iron-overload myopathy in a dog.
血色素沉着症在家畜中罕见，兽医领域尚未报道过铁诱导的肌病。本病例是首例关于犬血色素沉着症所致铁过载性肌病的报告。
一只9岁已绝育的雌性东京东洋犬出现严重的前肢跛行。尸检发现肝脏肿大以及前肢肌肉有出血性病变。显微镜检查显示铁成分在包括肝脏、前肢骨骼肌、脾脏、淋巴结和肾脏在内的多个器官中蓄积。普鲁士蓝染色确定巨噬细胞和实质细胞中均有铁沉积，表明铁蓄积是后天获得而非遗传性的。此外，在肌纤维内观察到铁成分，伴有严重萎缩和肌炎。
在肝脏和前肢骨骼肌中观察到严重坏死和轻度纤维化。基于组织学分析，我们诊断该病例为继发性血色素沉着症所致的铁过载性肌病。伴有严重肌肉萎缩和肌炎的继发性血色素沉着症非常罕见，这是犬铁过载性肌病的首例报告。
