Dorigo B, Raspanti D, Trapani M, Albanese B, Cameli A M, Digiesi V
Minerva Med. 1985 Feb 25;76(7):269-75.
Ten subjects with peripheral arterial occlusive disease were treated with buflomedil, analysing the effect of every single intravenous administration of the drug, and the effect of the administration repeated for a period of 5 days. This controlled study was aimed at evaluating the state of the peripheral blood flow, not just relating to the flowmetric parameters, but also to those more directly connected to the metabolic and functional conditions of the microcirculation. During every single administration, blood flow, skin and muscular temperatures were recorded. As concerned the drug's chronic effect, endurance limit, skin and muscular temperatures, whole blood viscosity, plasma viscosity and red cell filterability were recorded before beginning the treatment and after 15 days. The results of this study show that during a single buflomedil infusion no modifications have been observed in blood flow and muscular temperature, whereas skin temperature showed a slight increase. On the contrary, after a 15 days treatment, muscular temperature and endurance limit significantly increased, without flowmetric changes. A significant decrease in values of blood viscosity at high shear-rate was recorded too. The overall results seem to indicate that after treatment with buflomedil there is an improvement of the metabolic muscular conditions, probably due to a stimulant effect of the drug on microcirculatory blood flow.
对10名外周动脉闭塞性疾病患者使用丁咯地尔进行治疗，分析每次静脉给药的效果以及连续5天重复给药的效果。这项对照研究旨在评估外周血流状态，不仅涉及血流测量参数，还涉及那些与微循环代谢和功能状况更直接相关的参数。在每次给药期间，记录血流量、皮肤和肌肉温度。关于该药物的长期效果，在治疗开始前和15天后记录耐力极限、皮肤和肌肉温度、全血粘度、血浆粘度和红细胞过滤性。这项研究的结果表明，在单次输注丁咯地尔期间，未观察到血流量和肌肉温度有变化，而皮肤温度略有升高。相反，经过15天的治疗后，肌肉温度和耐力极限显著升高，血流测量无变化。高剪切率下的血液粘度值也显著降低。总体结果似乎表明，使用丁咯地尔治疗后，肌肉代谢状况有所改善，这可能是由于该药物对微循环血流的刺激作用。
