一个强大的内部启动子驱动YEATS结构域缺失的MLLT3转录本在造血干细胞和大多数致死性急性髓系白血病中大量表达。 - Suppr

A strong internal promoter drives massive expression of YEATS-domain devoid MLLT3 transcripts in HSC and most lethal AML.

作者信息

Bessière Chloé, Zamani Ahmed, Pfeifer Romain, Dailhau Sandra, Marchet Camille, Guibert Benoit, Boureux Anthony, Silva Da Silva Raïssa, Gilbert Nicolas, Commes Thérèse, Meggetto Fabienne, Touriol Christian, Récher Christian, Bousquet Marina, Pyronnet Stéphane

机构信息

Cancer Research Center of Toulouse, INSERM UMR-1037, CNRS UMR-5071, Toulouse University, Toulouse, France.

Institute for Regenerative Medicine and Biotherapy, INSERM UMR-1183, Saint-Éloi Hospital, Montpellier University, Montpellier, France.

出版信息

Cancer Commun (Lond). 2025 Mar;45(3):380-385. doi: 10.1002/cac2.12650. Epub 2025 Jan 3.

DOI:10.1002/cac2.12650

PMID:39749706

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11947615/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b77/11947615/5d4df04e89e3/CAC2-45-380-g001.jpg

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Nature. 2019 Dec;576(7786):281-286. doi: 10.1038/s41586-019-1790-2. Epub 2019 Nov 27.

Differential Regulation of the Three Eukaryotic mRNA Translation Initiation Factor (eIF) 4Gs by the Proteasome.

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Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain.

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A strong internal promoter drives massive expression of YEATS-domain devoid MLLT3 transcripts in HSC and most lethal AML.

作者信息

机构信息

Cancer Research Center of Toulouse, INSERM UMR-1037, CNRS UMR-5071, Toulouse University, Toulouse, France.

Institute for Regenerative Medicine and Biotherapy, INSERM UMR-1183, Saint-Éloi Hospital, Montpellier University, Montpellier, France.

出版信息

Cancer Commun (Lond). 2025 Mar;45(3):380-385. doi: 10.1002/cac2.12650. Epub 2025 Jan 3.

DOI:10.1002/cac2.12650

PMID:39749706

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11947615/

Abstract

摘要

相似文献

A strong internal promoter drives massive expression of YEATS-domain devoid MLLT3 transcripts in HSC and most lethal AML.

Cancer Commun (Lond). 2025 Mar;45(3):380-385. doi: 10.1002/cac2.12650. Epub 2025 Jan 3.

The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) - Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer.

J Mol Biol. 2022 Jan 15;434(1):167117. doi: 10.1016/j.jmb.2021.167117. Epub 2021 Jun 23.

Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.

Bioorg Med Chem Lett. 2024 Jan 15;98:129546. doi: 10.1016/j.bmcl.2023.129546. Epub 2023 Nov 7.

Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9.

SLAS Discov. 2019 Feb;24(2):133-141. doi: 10.1177/2472555218809904. Epub 2018 Oct 25.

Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable Studies: Discovery of TDI-11055.

ACS Med Chem Lett. 2024 Mar 12;15(4):524-532. doi: 10.1021/acsmedchemlett.4c00016. eCollection 2024 Apr 11.

The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia.

Leukemia. 2023 Jan;37(1):190-201. doi: 10.1038/s41375-022-01765-0. Epub 2022 Nov 26.

HMX3 is a critical vulnerability in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia.

Leukemia. 2025 Feb;39(2):371-380. doi: 10.1038/s41375-024-02485-3. Epub 2024 Dec 4.

Taf14 is required for the stabilization of transcription pre-initiation complex in Saccharomyces cerevisiae.

Epigenetics Chromatin. 2020 May 27;13(1):24. doi: 10.1186/s13072-020-00347-7.

Discovery of an MLLT1/3 YEATS Domain Chemical Probe.

Angew Chem Int Ed Engl. 2018 Dec 10;57(50):16302-16307. doi: 10.1002/anie.201810617. Epub 2018 Nov 16.

Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia.

ACS Cent Sci. 2021 May 26;7(5):815-830. doi: 10.1021/acscentsci.0c01550. Epub 2021 Apr 30.

本文引用的文献

Differential prognostic values of the three AKT isoforms in acute myeloid leukemia.

Sci Rep. 2024 Mar 25;14(1):7070. doi: 10.1038/s41598-024-57578-x.

The KMT2A recombinome of acute leukemias in 2023.

Leukemia. 2023 May;37(5):988-1005. doi: 10.1038/s41375-023-01877-1. Epub 2023 Apr 5.

The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) - Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer.

J Mol Biol. 2022 Jan 15;434(1):167117. doi: 10.1016/j.jmb.2021.167117. Epub 2021 Jun 23.

MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment.

Nature. 2019 Dec;576(7786):281-286. doi: 10.1038/s41586-019-1790-2. Epub 2019 Nov 27.

Differential Regulation of the Three Eukaryotic mRNA Translation Initiation Factor (eIF) 4Gs by the Proteasome.

Front Genet. 2019 Mar 29;10:254. doi: 10.3389/fgene.2019.00254. eCollection 2019.

Functional genomic landscape of acute myeloid leukaemia.

Nature. 2018 Oct;562(7728):526-531. doi: 10.1038/s41586-018-0623-z. Epub 2018 Oct 17.

Long non-coding RNA expression profile in cytogenetically normal acute myeloid leukemia identifies a distinct signature and a new biomarker in NPM1-mutated patients.

Haematologica. 2017 Oct;102(10):1718-1726. doi: 10.3324/haematol.2017.171645. Epub 2017 Jul 4.

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain.

Mol Cell. 2016 Apr 21;62(2):181-193. doi: 10.1016/j.molcel.2016.03.028.

AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation.

Cell. 2014 Oct 23;159(3):558-71. doi: 10.1016/j.cell.2014.09.049.

MLL targets SET domain methyltransferase activity to Hox gene promoters.

Mol Cell. 2002 Nov;10(5):1107-17. doi: 10.1016/s1097-2765(02)00741-4.

A strong internal promoter drives massive expression of YEATS-domain devoid MLLT3 transcripts in HSC and most lethal AML.

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A strong internal promoter drives massive expression of YEATS-domain devoid MLLT3 transcripts in HSC and most lethal AML.

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