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胰岛素样生长因子-2 mRNA结合蛋白-2基因多态性与2型糖尿病之间的显著关联：一项基于人群的病例对照研究。

Significant Association Between Genetic Polymorphism of Insulin-Like Growth Factor-2 mRNA Binding Protein-2 and Type 2 Diabetes Mellitus: A Population-Based Case-Control Study.

作者信息

Elssaig Elmutuz H, Ahmed-Abakur Eltayib H, Alnour Tarig M S, Alsubai Mohammed A, Ali Abdalla Eltoum, Ullah Mohammad Fahad, Saeedi Nizar H, Alenzi Fahad Daefalah

机构信息

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.

Prince Fahad Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia.

出版信息

J Clin Lab Anal. 2025 Feb;39(3):e25147. doi: 10.1002/jcla.25147. Epub 2025 Jan 3.

DOI:10.1002/jcla.25147
PMID:39749895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11821720/
Abstract

OBJECTIVES

To determine the association between IGF2BP2 polymorphisms and type 2 diabetes mellitus.

METHODS

This study involved 422 individuals, 214 diabetes mellitus cases, and 208 healthy controls. The PCR-RFLP technique was used to determine the genotype of the IGF2BP2 gene for the SNPs rs4402960 (G>T) and rs1470579 (A>C).

RESULTS

The results showed that the C allele of the rs1470579 variant and the T allele of the rs440960 variant were significantly associated with type 2 diabetes mellitus group (p = 0.0029 and 0.0001) as reported for both alleles, respectively. High frequencies of haplotypes TA and TC were observed in type 2 diabetes patients.

CONCLUSION

The present study showed that IGF2BP2 rs1470579 and rs4402960 polymorphism were significantly associated with the increased risk of T2DM in the Saudi Arabian population and presented a genetic model to screen the high-risk individuals with further validations.

摘要

目的

确定IGF2BP2基因多态性与2型糖尿病之间的关联。

方法

本研究纳入422名个体，其中214例糖尿病患者和208名健康对照。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术检测单核苷酸多态性（SNP）rs4402960（G>T）和rs1470579（A>C）的IGF2BP2基因的基因型。

结果

结果显示，rs1470579变异体的C等位基因和rs440960变异体的T等位基因分别与2型糖尿病组显著相关（p分别为0.0029和0.0001）。在2型糖尿病患者中观察到单倍型TA和TC的高频率。

结论

本研究表明，IGF2BP2 rs1470579和rs4402960多态性与沙特阿拉伯人群中2型糖尿病风险增加显著相关，并提出了一个遗传模型，有待进一步验证以筛查高危个体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/11821720/54ac5755ee80/JCLA-39-e25147-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/11821720/1968da3521ea/JCLA-39-e25147-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/11821720/5f06c7530208/JCLA-39-e25147-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/11821720/80d424e7ef04/JCLA-39-e25147-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/11821720/767b2f123c1d/JCLA-39-e25147-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/11821720/54ac5755ee80/JCLA-39-e25147-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/11821720/1968da3521ea/JCLA-39-e25147-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/11821720/5f06c7530208/JCLA-39-e25147-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/11821720/80d424e7ef04/JCLA-39-e25147-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/11821720/767b2f123c1d/JCLA-39-e25147-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/11821720/54ac5755ee80/JCLA-39-e25147-g006.jpg

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