Department of Endocrinology and Metabolism, The Second People's Hospital of Yunnan Province & The Affiliated Hospital of Yunnan University, Kunming 650021, Yunnan, China.
Dali University, Dali 671000, Yunnan, China.
Int J Med Sci. 2021 Jan 1;18(2):356-363. doi: 10.7150/ijms.53004. eCollection 2021.
Type 2 diabetes mellitus (T2DM) is a complex chronic metabolic disorder triggered by insulin resistance in peripheral tissues. Evidence has shown that lipid metabolism and related genetic factors lead to insulin resistance. Hence, it is meaningful to investigate the association between single-nucleotide polymorphisms (SNPs) in lipid metabolism-related genes and T2DM. A total of 1,194 subjects with T2DM and 1,274 Non-diabetic subjects (NDM) were enrolled. Five SNPs in three genes (rs864745 in , rs35767 in , and rs4376068, rs4402960, and rs6769511 in ) that contribute to insulin resistance involving lipid metabolism were genotyped using the MassArray method in a Chinese population. The allele and genotypes of rs6769511 in were associated with T2DM (P=0.009 and P=0.002, respectively). In inheritance model analysis, compared with the T/T-C/T genotype, the C/C genotype of rs6769511 in was a risk factor for the development of T2DM (P<0.001, odds ratio [OR] =1.76; 95% confidence interval [CI]: 1.29-2.42). Haplotype analysis revealed associations of the rs4376068-rs4402960-rs6769511 haplotypes in with the development of T2DM (P=0.015). Additionally, rs4376068C-rs4402960T-rs6769511C was a risk haplotype for T2DM (OR=1.179; 95% CI: 1.033-1.346). The rs6769511 in was associated with T2DM susceptibility, and the rs4376068-rs4402960-rs6769511 haplotypes in was associated with the development of T2DM in a Chinese population.
2 型糖尿病（T2DM）是一种由外周组织胰岛素抵抗引起的复杂慢性代谢紊乱。有证据表明，脂代谢和相关的遗传因素导致胰岛素抵抗。因此，研究脂代谢相关基因中单核苷酸多态性（SNP）与 T2DM 之间的关系具有重要意义。本研究共纳入 1194 例 T2DM 患者和 1274 例非糖尿病患者（NDM）。采用 MassArray 方法对中国人群中三个基因（ 中的 rs864745、 中的 rs35767 和 中的 rs4376068、rs4402960 和 rs6769511）中与胰岛素抵抗相关的 5 个 SNP 进行基因分型。 中的 rs6769511 等位基因和基因型与 T2DM 相关（P=0.009 和 P=0.002）。在遗传模型分析中，与 T/T-C/T 基因型相比， 中的 rs6769511 的 C/C 基因型是 T2DM 发生的危险因素（P<0.001，优势比[OR] =1.76；95%置信区间[CI]：1.29-2.42）。单体型分析显示 中的 rs4376068-rs4402960-rs6769511 单体型与 T2DM 的发生相关（P=0.015）。此外，rs4376068C-rs4402960T-rs6769511C 是 T2DM 的风险单体型（OR=1.179；95%CI：1.033-1.346）。 中的 rs6769511 与 T2DM 易感性相关， 中的 rs4376068-rs4402960-rs6769511 单体型与中国人群 T2DM 的发生相关。
