Barsoum Michael L, Fahy Kira M, Morris William, Dravid Vinayak P, Hernandez Benjamin, Farha Omar K
Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
ACS Nano. 2025 Jan 14;19(1):13-20. doi: 10.1021/acsnano.4c14744. Epub 2025 Jan 3.
This perspective highlights the transformative potential of Metal-Organic Frameworks (MOFs) in environmental and healthcare sectors. It discusses work that has advanced beyond technology readiness levels of >4 including applications in capture, storage, and conversion of gases to value added products. This work showcases efforts in the most salient applications of MOFs which have been performed at a great cadence, enabled by the federal government, large companies, and startups to commercialize these technologies despite facing significant challenges. This article also forecasts the role of nanoscale MOFs in healthcare, including strides toward personalized medicine, advocating for their use in custom-tailored drug delivery systems. Finally we underscore the potential acceleration in MOF research and development through the integration of machine learning and AI, positioning MOFs as versatile tools poised to address global sustainability and health challenges.
这一观点突出了金属有机框架材料（MOFs）在环境和医疗保健领域的变革潜力。它讨论了技术就绪水平已超过4级的相关工作，包括气体捕获、储存以及转化为增值产品等应用。这项工作展示了MOFs在最显著应用方面所做的努力，这些努力在联邦政府、大公司和初创企业的推动下，以很高的频率进行，尽管面临重大挑战，但仍致力于将这些技术商业化。本文还预测了纳米级MOFs在医疗保健中的作用，包括在个性化医疗方面取得的进展，倡导其在定制药物递送系统中的应用。最后，我们强调通过整合机器学习和人工智能，MOF研发可能加速，使MOFs成为应对全球可持续发展和健康挑战的通用工具。
