组织驻留自然杀伤细胞进行自身的腺体塑造。
Tissue-resident NK cells do their own glandscaping.
作者信息
Myers Jacob A, Reilly Shanelle P, Brossay Laurent
机构信息
Division of Biology and Medicine, Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
出版信息
J Exp Med. 2025 Mar 3;222(3). doi: 10.1084/jem.20242253. Epub 2025 Jan 3.
Abstract
In this issue of JEM, Sparano et al. (https://doi.org/10.1084/jem.20240930) present compelling evidence that salivary gland trNK cells originate from cNK cells and are developmentally distinct from ILC1 cells. Mechanistically, they demonstrate that continuous autocrine TGF-β signaling drives salivary gland tissue residency and works in synergy with IL-15 to enhance Hobit-dependent cytotoxicity.
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本文引用的文献
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NK cells restrain cytotoxic CD8 T cells in the submandibular gland via PD-1-PD-L1.自然杀伤细胞通过程序性死亡蛋白1-程序性死亡配体1途径在下颌下腺中抑制细胞毒性CD8 T细胞。
Sci Immunol. 2024 Dec 20;9(102):eadl2967. doi: 10.1126/sciimmunol.adl2967.
2
Embryonic and neonatal waves generate distinct populations of hepatic ILC1s.胚胎期和新生儿期的波产生了不同的肝 ILC1 群体。
Sci Immunol. 2022 Sep 2;7(75):eabo6641. doi: 10.1126/sciimmunol.abo6641.
3
Salivary gland NK cells are phenotypically and functionally unique.唾液腺 NK 细胞具有独特的表型和功能。
PLoS Pathog. 2011 Jan 13;7(1):e1001254. doi: 10.1371/journal.ppat.1001254.
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