• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

转化生长因子-β信号传导指导唾液腺中固有淋巴细胞的分化。

Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands.

作者信息

Cortez Victor S, Cervantes-Barragan Luisa, Robinette Michelle L, Bando Jennifer K, Wang Yaming, Geiger Theresa L, Gilfillan Susan, Fuchs Anja, Vivier Eric, Sun Joe C, Cella Marina, Colonna Marco

机构信息

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63108, USA.

Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

出版信息

Immunity. 2016 May 17;44(5):1127-39. doi: 10.1016/j.immuni.2016.03.007. Epub 2016 May 3.

DOI:10.1016/j.immuni.2016.03.007
PMID:27156386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5114145/
Abstract

The signals guiding differentiation of innate lymphoid cells (ILCs) within tissues are not well understood. Salivary gland (SG) ILCs as well as liver and intestinal intraepithelial ILC1 have markers that denote tissue residency and transforming growth factor-β (TGF-β) imprinting. We deleted Tgfbr2 in cells expressing the ILC and NK marker NKp46 and found that SG ILCs were reduced in number. They lost distinct tissue markers, such as CD49a, and the effector molecules TRAIL and CD73. Expression of the transcription factor Eomes, which promotes NK cell differentiation, was elevated. Conversely, Eomes deletion in NKp46(+) cells enhanced TGF-β-imprinting of SG ILCs. Thus, TGF-β induces SG ILC differentiation by suppressing Eomes. TGF-β acted through a JNK-dependent, Smad4-independent pathway. Transcriptome analysis demonstrated that SG ILCs had characteristic of both NK cells and ILC1. Finally, TGF-β imprinting of SG ILCs was synchronized with SG development, highlighting the impact of tissue microenvironment on ILC development.

摘要

指导组织内固有淋巴细胞（ILC）分化的信号尚未完全清楚。唾液腺（SG）ILC以及肝脏和肠道上皮内ILC1具有表示组织驻留和转化生长因子-β（TGF-β）印记的标志物。我们在表达ILC和NK标志物NKp46的细胞中删除了Tgfbr2，发现SG ILC的数量减少。它们失去了独特的组织标志物，如CD49a，以及效应分子TRAIL和CD73。促进NK细胞分化的转录因子Eomes的表达升高。相反，在NKp46(+)细胞中删除Eomes增强了SG ILC的TGF-β印记。因此，TGF-β通过抑制Eomes诱导SG ILC分化。TGF-β通过JNK依赖、Smad4非依赖的途径发挥作用。转录组分析表明，SG ILC具有NK细胞和ILC1的特征。最后，SG ILC的TGF-β印记与SG发育同步，突出了组织微环境对ILC发育的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/2e02f759540e/nihms-770958-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/d5ab85bd1099/nihms-770958-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/98fdaff95aca/nihms-770958-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/de387e85c74e/nihms-770958-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/a55265b1cca3/nihms-770958-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/eb68057c9860/nihms-770958-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/d0a6319eed0d/nihms-770958-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/2e02f759540e/nihms-770958-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/d5ab85bd1099/nihms-770958-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/98fdaff95aca/nihms-770958-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/de387e85c74e/nihms-770958-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/a55265b1cca3/nihms-770958-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/eb68057c9860/nihms-770958-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/d0a6319eed0d/nihms-770958-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e1/5114145/2e02f759540e/nihms-770958-f0008.jpg

相似文献

1
Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands.转化生长因子-β信号传导指导唾液腺中固有淋巴细胞的分化。
Immunity. 2016 May 17;44(5):1127-39. doi: 10.1016/j.immuni.2016.03.007. Epub 2016 May 3.
2
A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties.一种以1型特性为特征的小鼠肠道上皮内NKp46阴性固有淋巴细胞群体。
Cell Rep. 2017 May 16;19(7):1431-1443. doi: 10.1016/j.celrep.2017.04.068.
3
The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway.转录因子 T-bet 通过 Notch 通路对 NKp46+固有淋巴细胞的发育至关重要。
Nat Immunol. 2013 Apr;14(4):389-95. doi: 10.1038/ni.2545. Epub 2013 Mar 3.
4
NK1.1 innate lymphoid cells in salivary glands inhibit establishment of tissue-resident memory CD8 T cells in mice.唾液腺中的 NK1.1 固有淋巴细胞抑制组织驻留记忆 CD8 T 细胞在小鼠中的建立。
Eur J Immunol. 2020 Dec;50(12):1952-1958. doi: 10.1002/eji.202048741. Epub 2020 Aug 17.
5
Cytomegalovirus Evades TRAIL-Mediated Innate Lymphoid Cell 1 Defenses.巨细胞病毒逃避 TRAIL 介导的固有淋巴细胞 1 防御。
J Virol. 2019 Jul 30;93(16). doi: 10.1128/JVI.00617-19. Print 2019 Aug 15.
6
Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity.Eomes 在成熟 NK 细胞稳态和细胞毒性中的阶段特异性需求。
Cell Rep. 2020 Jun 2;31(9):107720. doi: 10.1016/j.celrep.2020.107720.
7
SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling.SMAD4通过抑制非经典TGF-β信号传导来阻碍自然杀伤细胞向ILC1样细胞的转化。
Nat Immunol. 2017 Sep;18(9):995-1003. doi: 10.1038/ni.3809. Epub 2017 Jul 31.
8
The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.转录因子 HIF-1α 介导肠道中 NKp46+固有淋巴细胞的可塑性。
J Exp Med. 2022 Feb 7;219(2). doi: 10.1084/jem.20210909. Epub 2022 Jan 13.
9
Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes.激活素受体样激酶 5 抑制通过泛素化降解 Smad4 抑制小鼠黑色素瘤，从而在细胞毒性 T 淋巴细胞中解除 Eomesodermin 的抑制。
EMBO Mol Med. 2013 Nov;5(11):1720-39. doi: 10.1002/emmm.201302524. Epub 2013 Oct 11.
10
TCF-1 controls ILC2 and NKp46+RORγt+ innate lymphocyte differentiation and protection in intestinal inflammation.TCF-1 控制 ILC2 和 NKp46+RORγt+ 固有淋巴细胞的分化和在肠道炎症中的保护作用。
J Immunol. 2013 Oct 15;191(8):4383-91. doi: 10.4049/jimmunol.1301228. Epub 2013 Sep 13.

引用本文的文献

1
Natural killer cells in skin: a unique opportunity to better characterize the many facets of an overlooked secondary lymphoid organ.皮肤中的自然杀伤细胞：深入了解一个被忽视的二级淋巴器官多方面特性的独特契机。
Front Immunol. 2025 Aug 12;16:1646719. doi: 10.3389/fimmu.2025.1646719. eCollection 2025.
2
Dissecting the heterogeneity and tumor-associated dynamics of human liver group I ILC via scRNA sequencing data.通过单细胞RNA测序数据剖析人类肝脏I型固有淋巴细胞的异质性和肿瘤相关动态变化。
Immunol Res. 2025 Aug 23;73(1):122. doi: 10.1007/s12026-025-09665-y.
3
Innate Lymphoid Cells.

本文引用的文献

1
Tissue-resident memory T cells: local specialists in immune defence.组织驻留记忆 T 细胞：免疫防御的局部专家。
Nat Rev Immunol. 2016 Feb;16(2):79-89. doi: 10.1038/nri.2015.3. Epub 2015 Dec 21.
2
Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs.固有淋巴细胞在淋巴器官和非淋巴器官中的组织驻留。
Science. 2015 Nov 20;350(6263):981-5. doi: 10.1126/science.aac9593. Epub 2015 Oct 15.
3
Runx3 specifies lineage commitment of innate lymphoid cells.Runx3决定天然淋巴细胞的谱系定向。
固有淋巴细胞
Adv Exp Med Biol. 2025;1476:31-46. doi: 10.1007/978-3-031-85340-1_2.
4
Dendritic Cell-Based Cancer Vaccines: The Impact of Modulating Innate Lymphoid Cells on Anti-Tumor Efficacy.基于树突状细胞的癌症疫苗：调节固有淋巴细胞对抗肿瘤疗效的影响
Cells. 2025 May 30;14(11):812. doi: 10.3390/cells14110812.
5
JEG-3 Trophoblast Cells Influence ILC-like Transformation of NK Cells In Vitro.JEG-3滋养层细胞在体外影响自然杀伤细胞向类固有淋巴细胞的转化。
Int J Mol Sci. 2025 Apr 14;26(8):3687. doi: 10.3390/ijms26083687.
6
A membrane lipid signature unravels the dynamic landscape of group 1 innate lymphoid cells across the health-disease continuum.一种膜脂质特征揭示了1型天然淋巴细胞在健康-疾病连续体中的动态格局。
iScience. 2025 Feb 17;28(3):112043. doi: 10.1016/j.isci.2025.112043. eCollection 2025 Mar 21.
7
The ontogeny of mouse salivary gland macrophages is distinct between genders.小鼠唾液腺巨噬细胞的个体发育在性别之间存在差异。
Res Sq. 2025 Feb 6:rs.3.rs-5903499. doi: 10.21203/rs.3.rs-5903499/v1.
8
Transcriptional signature of CD56 NK cells predicts favourable prognosis in bladder cancer.CD56自然杀伤细胞的转录特征预示膀胱癌预后良好。
Front Immunol. 2025 Jan 14;15:1474652. doi: 10.3389/fimmu.2024.1474652. eCollection 2024.
9
NKp46 enhances type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity.NKp46增强1型天然淋巴细胞的增殖和功能以及抗急性髓系白血病活性。
Nat Commun. 2025 Jan 24;16(1):989. doi: 10.1038/s41467-025-55923-w.
10
Tissue-resident immune cells: from defining characteristics to roles in diseases.组织驻留免疫细胞：从定义特征到在疾病中的作用
Signal Transduct Target Ther. 2025 Jan 17;10(1):12. doi: 10.1038/s41392-024-02050-5.
Nat Immunol. 2015 Nov;16(11):1124-33. doi: 10.1038/ni.3272. Epub 2015 Sep 28.
4
Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology.固有淋巴细胞。固有淋巴细胞：免疫学的新范式。
Science. 2015 May 22;348(6237):aaa6566. doi: 10.1126/science.aaa6566. Epub 2015 May 21.
5
NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors.NFIL3 调控常见辅助先天淋巴细胞前体的出现。
Cell Rep. 2015 Mar 31;10(12):2043-54. doi: 10.1016/j.celrep.2015.02.057. Epub 2015 Mar 19.
6
Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML.肌醇多磷酸 4-磷酸酶 II（INPP4B）与 AML 中的化疗耐药和不良预后相关。
Blood. 2015 Apr 30;125(18):2815-24. doi: 10.1182/blood-2014-09-603555. Epub 2015 Mar 3.
7
Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cells.Smad4促进效应性和循环记忆性CD8 T细胞的分化，但对于组织驻留记忆性CD8 T细胞来说并非必需。
J Immunol. 2015 Mar 1;194(5):2407-14. doi: 10.4049/jimmunol.1402369. Epub 2015 Jan 30.
8
Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets.转录程序定义了先天淋巴细胞类和亚类的分子特征。
Nat Immunol. 2015 Mar;16(3):306-17. doi: 10.1038/ni.3094. Epub 2015 Jan 26.
9
Tissue-resident memory T cells.组织驻留记忆T细胞
Immunity. 2014 Dec 18;41(6):886-97. doi: 10.1016/j.immuni.2014.12.007. Epub 2014 Dec 6.
10
TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity.TRAIL+ NK 细胞在慢性病毒感染期间控制 CD4+ T 细胞反应，以限制自身免疫。
Immunity. 2014 Oct 16;41(4):646-56. doi: 10.1016/j.immuni.2014.09.013.