Ogata Dai, Namikawa Kenjiro, Nakano Eiji, Fujimori Maiko, Uchitomi Yosuke, Higashi Takahiro, Satake Tomoyuki, Morizane Chigusa, Yamazaki Naoya, Kawai Akira
Department of Dermatologic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 1040045, Japan.
Rare Cancer Center, National Cancer Center, Tokyo, Japan.
Int J Clin Oncol. 2025 Feb;30(2):194-198. doi: 10.1007/s10147-024-02675-0. Epub 2025 Jan 3.
Melanoma is a highly malignant cancer responsible for 55 000 deaths worldwide annually. Despite its severity, its epidemiology in Japan remains understudied owing to its rarity among Asians. This study aimed to determine the incidence of melanoma in Japan using data from the National Cancer Registry.
We analyzed data from patients diagnosed with melanoma in 2016 and 2017, classifying cases according to subtype using the World Health Organization (WHO) and other tumor classifications. Tumor incidence was calculated as the number of new cases divided by the corresponding population per year.
A total of 6176 patients were included in the study. The subtypes were distributed as follows: cutaneous (76.2%), mucosal (19.6%), uveal (2.7%), and neural organ/unknown primary melanoma (1.3%). The overall age-adjusted incidence of melanoma was 2.57 per 100 000 persons in the Japanese and 1.15 per 100 000 persons in the WHO population models.
This study provided comprehensive epidemiological data on melanoma in Japan using population-based registry data, highlighting the relatively low incidence of melanoma compared with that worldwide and emphasizing the need for further research into its unique epidemiology in Asian populations.
黑色素瘤是一种高度恶性的癌症，每年在全球导致55000人死亡。尽管其严重性，但由于其在亚洲人中较为罕见，其在日本的流行病学仍未得到充分研究。本研究旨在利用国家癌症登记处的数据确定日本黑色素瘤的发病率。
我们分析了2016年和2017年被诊断为黑色素瘤的患者的数据，根据世界卫生组织（WHO）和其他肿瘤分类方法对病例进行亚型分类。肿瘤发病率计算为每年新发病例数除以相应人口数。
共有6176名患者纳入研究。亚型分布如下：皮肤型（76.2%）、黏膜型（19.6%）、葡萄膜型（2.7%）和神经器官/原发灶不明黑色素瘤（1.3%）。日本黑色素瘤的总体年龄调整发病率为每10万人2.57例，在世卫组织人口模型中为每10万人1.15例。
本研究利用基于人群的登记数据提供了日本黑色素瘤的全面流行病学数据，突出了与全球相比黑色素瘤相对较低的发病率，并强调需要进一步研究其在亚洲人群中的独特流行病学。
