Schnur P
Pharmacol Biochem Behav. 1985 Jan;22(1):157-8. doi: 10.1016/0091-3057(85)90500-3.
The effects of morphine on hamster locomotor activity were studied. Repeated administration of morphine in doses from 5 to 40 mg/kg produced systematic changes in morphine's biphasic time effect pattern: morphine's sedative effects decreased (tolerance) while morphine's excitatory effects increased (sensitization). These results extend findings of behavioral tolerance and sensitization in the hamster to a range of higher doses than those used previously.
研究了吗啡对仓鼠运动活动的影响。重复给予5至40毫克/千克剂量的吗啡会使吗啡的双相时间效应模式产生系统性变化：吗啡的镇静作用减弱（耐受性），而吗啡的兴奋作用增强（敏化作用）。这些结果将仓鼠行为耐受性和敏化作用的研究结果扩展到了比以前使用的剂量更高的范围。
