Schnur P, Cesar S S, Foderaro M A, Kulkosky P J
Department of Psychology, University of Southern Colorado, Pueblo 81001-4901.
Pharmacol Biochem Behav. 1991 Jul;39(3):581-6. doi: 10.1016/0091-3057(91)90131-k.
The effects of the octapeptide cholecystokinin (CCK) on hamster locomotor activity were investigated in three experiments. In Experiment 1, the effect of CCK (25, 50, 75 micrograms/kg) on morphine (2.5 mg/kg)-elicited hyperactivity was studied. Results indicated that CCK antagonized morphine-elicited hyperactivity and that CCK alone elicited hypoactivity. There were no effects of dose of CCK. In Experiment 2, the effects of intraperitoneal (IP) and subcutaneous (SC) routes of administration of CCK (25 micrograms/kg) on locomotor activity were studied. Compared to saline controls, CCK induced hypoactivity that was of greater magnitude and of longer duration when administered IP than SC. Experiment 3 was designed to replicate the route of administration effect observed in Experiment 2 and to determine whether sensitization to CCK-induced hypoactivity develops over the course of a few injections. Results indicated that CCK-induced hypoactivity was greater after IP than SC administration but that sensitization was not detectable. It is concluded that CCK antagonizes morphine-elicited hyperactivity in the hamster by acting, in part, independently of morphine to produce opposite behavioral effects.
在三个实验中研究了八肽胆囊收缩素（CCK）对仓鼠运动活动的影响。在实验1中，研究了CCK（25、50、75微克/千克）对吗啡（2.5毫克/千克）引起的活动亢进的影响。结果表明，CCK拮抗吗啡引起的活动亢进，且CCK单独使用会引起活动减退。CCK的剂量没有影响。在实验2中，研究了腹腔注射（IP）和皮下注射（SC）CCK（25微克/千克）对运动活动的影响。与生理盐水对照组相比，CCK引起活动减退，腹腔注射时其程度更大、持续时间更长，相比皮下注射。实验3旨在重复实验2中观察到的给药途径效应，并确定对CCK引起的活动减退的敏感性是否会在几次注射过程中产生。结果表明，腹腔注射后CCK引起的活动减退比皮下注射更大，但未检测到敏感性。得出的结论是，CCK通过部分独立于吗啡发挥作用以产生相反的行为效应，从而拮抗仓鼠中吗啡引起的活动亢进。
