Yang Wen-Xia, Su Ke, Liao Min-Chun, Zhou Jing, Peng Junzheng, Hébert Marie-Josée, Leal Daniel N, Yamashita Michifumi, Miyata Kana N, Filep Janos G, Ingelfinger Julie R, Zhang Shao-Ling, Chan John S D
Centre de Recherche, Centre Hospitalier de l'Université de Montréal (CRCHUM) and Département de Médecine, Université de Montréal, Montréal, Quebec, Canada.
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Diabetes. 2025 Apr 1;74(4):554-568. doi: 10.2337/db24-0553.
Renin-angiotensin system (RAS) activation plays an important role in the progression of diabetic kidney disease (DKD). However, systemic RAS blockade alone is insufficient to reverse DKD progression. We hypothesized that intrarenal renin-angiotensin system (iRAS) activation plays a crucial role in the progression of DKD. We sought to elucidate the role of the iRAS in DKD progression. Selective deletion of angiotensinogen in renal tubules ameliorated the pathological features of DKD. Our study indicates that iRAS inactivation may be a potential approach for preventing DKD disease severity and its progression.
肾素-血管紧张素系统（RAS）激活在糖尿病肾病（DKD）进展中起重要作用。然而，仅全身性RAS阻断不足以逆转DKD进展。我们推测肾内肾素-血管紧张素系统（iRAS）激活在DKD进展中起关键作用。我们试图阐明iRAS在DKD进展中的作用。肾小管中血管紧张素原的选择性缺失改善了DKD的病理特征。我们的研究表明，iRAS失活可能是预防DKD疾病严重程度及其进展的一种潜在方法。
