数字健康干预研究中研究参与者的参与度与留存率：混合方法系统评价方案

Research Participants' Engagement and Retention in Digital Health Interventions Research: Protocol for Mixed Methods Systematic Review.

作者信息

Terceiro Luciana, Mustafa Mudassir Imran, Hägglund Maria, Kharko Anna

机构信息

Department of Women's and Children's Health, CIRCLE - Complex Intervention Research in Health and Care, Uppsala University, Uppsala, Sweden.

Department of Women's and Children's Health, Participatory eHealth and Health Data Research Group, Uppsala University, Uppsala, Sweden.

出版信息

JMIR Res Protoc. 2025 Jan 3;14:e65099. doi: 10.2196/65099.

DOI:10.2196/65099

PMID:39752662

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11748419/

Abstract

BACKGROUND

Digital health interventions have become increasingly popular in recent years, expanding the possibilities for treatment for various patient groups. In clinical research, while the design of the intervention receives close attention, challenges with research participant engagement and retention persist. This may be partially due to the use of digital health platforms, which may lack adequacy for participants.

OBJECTIVE

This systematic literature review aims to investigate the relationship between digital health platforms and participant engagement and retention in clinical research. It will map and analyze key definitions of engagement and retention, as well as identify design characteristics that influence them.

METHODS

We will carry out a mixed methods systematic literature review, analyzing qualitative and quantitative studies. The search strategy includes the electronic databases PubMed, IEEE Xplore, CINAHL, Scopus, Web of Science, APA PsycINFO, and the ACM Digital Library. The review will encompass studies published between January 2018 and June 2024. Criteria for inclusion will be the presence of digital health care interventions conducted through digital health platforms like websites, web and mobile apps used by patients, and informal caregivers as research participants. The main outcome will be a narrative analysis with key findings on the definitions of participant engagement and retention and critical factors that affect them. Quality assessment and appraisal will be done through the Mixed-Methods Assessment Tool. Data analysis and synthesis will follow the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 flow diagram. Quantitative data will be qualified and integrated into qualitative data, which will be analyzed using thematic analysis and synthesis.

RESULTS

The study expects to map and summarize critical definitions of participant engagement and retention, and the characteristics of digital health platforms that influence them. The systematic review is expected to be completed in June 2025.

CONCLUSIONS

This systematic review will contribute to the growing discussion on how the design of digital health intervention platforms can promote participant engagement and retention in clinical research.

TRIAL REGISTRATION

PROSPERO CRD42024561650; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=561650.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/65099.

摘要

背景

近年来，数字健康干预措施越来越受欢迎，为各类患者群体拓展了治疗可能性。在临床研究中，虽然干预措施的设计受到密切关注，但研究参与者的参与度和留存率仍面临挑战。这可能部分归因于数字健康平台的使用，这些平台可能对参与者来说不够完善。

目的

本系统文献综述旨在调查数字健康平台与临床研究中参与者的参与度和留存率之间的关系。它将梳理并分析参与度和留存率的关键定义，以及识别影响它们的设计特征。

方法

我们将进行一项混合方法的系统文献综述，分析定性和定量研究。检索策略包括电子数据库PubMed、IEEE Xplore、CINAHL、Scopus、Web of Science、APA PsycINFO和ACM数字图书馆。该综述将涵盖2018年1月至2024年6月期间发表的研究。纳入标准将是存在通过数字健康平台进行的数字医疗保健干预措施，如患者和非正式护理人员作为研究参与者使用的网站、网络和移动应用程序。主要结果将是对参与者参与度和留存率定义以及影响它们的关键因素的叙述性分析。质量评估和评价将通过混合方法评估工具进行。数据分析和综合将遵循PRISMA（系统评价和元分析的首选报告项目）2020流程图。定量数据将进行限定并整合到定性数据中，定性数据将使用主题分析和综合进行分析。