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肉桂酸可降低大鼠血压并逆转血管内皮功能障碍。

Cinnamic acid lowers blood pressure and reverses vascular endothelial dysfunction in rats.

作者信息

Shah Abdul Jabbar, Qamar Hafiz Misbah-Ud-Din, Salma Umme, Khan Taous

机构信息

Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.

Cardiovascular Research Group, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, University Road, Abbottabad-22060, KP, Pakistan.

出版信息

J Food Drug Anal. 2024 Dec 15;32(4):577-588. doi: 10.38212/2224-6614.3530.

DOI:10.38212/2224-6614.3530
PMID:39752866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11698596/
Abstract

Cinnamic acid (CA) possesses important cardiovascular effects such as cardioprotective, antiatherogenic, antihyperlipidemic and antioxidant, which predicts its potential role in the treatment of hypertension. The study was executed to investigate the antihypertensive potential of CA in Sprague Dawley (SD) rats followed by evaluation in diverse vascular preparations. Invasive blood pressure monitoring technique was used in normotensive and hypertensive rats, under anesthesia. Isolated aortic rings from rat and rabbit, Langendorrf's perfused isolated rabbit heart and guinea-pig right atria were used to probe the underlying mechanisms. The responses were recorded with pressure and force transducers connected to PowerLab Data Acquisition System. Intravenous administration of CA induced a respective 54% and 38% fall in mean arterial pressure (MAP) in the hypertensive and normotensive rats, respectively. In rat aortic rings, the CA exhibited muscarinic receptors-linked NO and indomethacin-sensitive endothelium-dependent (>50%) and calcium antagonistic and KATP-mediated endothelium-independent vasodilator effects. The CA showed negative inotropic and chronotropic effects in guinea-pig atrial strips. The CA suppressed force of ventricular contraction and heart rate while caused a 25% increase in coronary flow. This study supports the medicinal importance of CA as antihypertensive agent.

摘要

肉桂酸（CA）具有重要的心血管效应，如心脏保护、抗动脉粥样硬化、抗高血脂和抗氧化作用，这预示着它在高血压治疗中可能发挥的作用。本研究旨在探讨CA对Sprague Dawley（SD）大鼠的降压潜力，并在多种血管制剂中进行评估。在麻醉状态下，对正常血压和高血压大鼠使用有创血压监测技术。使用大鼠和兔的离体主动脉环、Langendorrf灌注的离体兔心脏和豚鼠右心房来探究其潜在机制。通过连接到PowerLab数据采集系统的压力和力传感器记录反应。静脉注射CA分别使高血压大鼠和正常血压大鼠的平均动脉压（MAP）下降了54%和38%。在大鼠主动脉环中，CA表现出与毒蕈碱受体相关的一氧化氮（NO）以及对吲哚美辛敏感的内皮依赖性（>50%）和钙拮抗及ATP敏感性钾通道（KATP）介导的内皮非依赖性血管舒张作用。CA在豚鼠心房条上表现出负性变力和变时作用。CA抑制心室收缩力和心率，同时使冠状动脉血流量增加25%。本研究支持了CA作为降压药物的药用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7b/11698596/7bcfdf0bc031/jfda-32-04-577f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7b/11698596/e1fce64150e2/jfda-32-04-577f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7b/11698596/beae587496f0/jfda-32-04-577f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7b/11698596/1cbcd2a12016/jfda-32-04-577f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7b/11698596/275549cca77f/jfda-32-04-577f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7b/11698596/7bcfdf0bc031/jfda-32-04-577f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7b/11698596/e1fce64150e2/jfda-32-04-577f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7b/11698596/cd6a9c5fc1e1/jfda-32-04-577f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7b/11698596/beae587496f0/jfda-32-04-577f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7b/11698596/1cbcd2a12016/jfda-32-04-577f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7b/11698596/275549cca77f/jfda-32-04-577f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7b/11698596/7bcfdf0bc031/jfda-32-04-577f6.jpg

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本文引用的文献

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Antihypertensive Activity of Sauromatum guttatum Mediated by Vasorelaxation and Myocardial Depressant Effects.土茯苓通过血管舒张和心肌抑制作用的降压活性。
Arq Bras Cardiol. 2021 Dec;117(6):1093-1103. doi: 10.36660/abc.20200055.
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Cinnamic Acid Derivatives and Their Biological Efficacy.肉桂酸衍生物及其生物功效。
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Multifunctional Cinnamic Acid Derivatives.多功能肉桂酸衍生物
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Discovery and Development of Calcium Channel Blockers.钙通道阻滞剂的发现与研发
Front Pharmacol. 2017 May 29;8:286. doi: 10.3389/fphar.2017.00286. eCollection 2017.
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Cinnamic Acid and Its Derivatives: Mechanisms for Prevention and Management of Diabetes and Its Complications.肉桂酸及其衍生物：糖尿病及其并发症的预防和管理机制
Nutrients. 2017 Feb 21;9(2):163. doi: 10.3390/nu9020163.
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Oxidative Stress and Hypertensive Diseases.氧化应激与高血压疾病
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