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女性原发性膀胱颈梗阻:来自印度尼西亚人群的病例系列

Primary bladder neck obstruction in females: Case series from the Indonesian population.

作者信息

Adzhani Adelia Anggasta, Laksita Tetuka Bagus, Renaldo Johan

机构信息

Department of Urology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Department of Urology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

出版信息

Int J Surg Case Rep. 2025 Jan;126:110799. doi: 10.1016/j.ijscr.2024.110799. Epub 2024 Dec 30.

Abstract

INTRODUCTION

Primary bladder neck obstruction (PBNO) is a rare but significant cause of BOO and LUTS in females, with unclear etiology involving theories of fibrotic narrowing, tissue hyperplasia, or muscle abnormalities. Due to nonspecific symptoms, PBNO diagnosis remains challenging, and optimal surgical treatment needs to be better defined.

CASE PRESENTATION

We report two cases of females in their 50s with recurrent urinary retention managed by indwelling catheters. The first, aged 58, experienced worsening LUTS over five months, requiring catheter use for two months. The second, aged 50, had persistent voiding difficulty and failed previous catheter trials. Both lacked a history of trauma, pelvic surgery, or significant comorbidities. Cystoscopy revealed bladder neck obstruction with moderate trabeculation of the detrusor muscle. Transurethral resection of the bladder neck (TURBN) was performed circumferentially. Postoperatively, both patients showed marked improvement, with uroflowmetry demonstrating maximum flow rates of 10.7 mL/s and 9.4 mL/s and minimal residual volumes. No incontinence or other complications were observed.

DISCUSSION

PBNO in females is underdiagnosed due to nonspecific presentations. Structural abnormalities and potential neurogenic factors are implicated in its pathophysiology. In our cases, TURBN effectively improved voiding function, underscoring its role for patients unresponsive to conservative therapy. However, data on long-term outcomes and risks, such as stress urinary incontinence, remain limited.

CONCLUSION

TURBN is a promising treatment for female PBNO, offering symptom relief and improved voiding function. Continued research is needed to refine techniques and develop evidence-based guidelines.

摘要

引言

原发性膀胱颈梗阻(PBNO)是女性膀胱出口梗阻(BOO)和下尿路症状(LUTS)的一种罕见但重要的病因,其病因尚不清楚,涉及纤维化狭窄、组织增生或肌肉异常等理论。由于症状不具特异性,PBNO的诊断仍然具有挑战性,最佳手术治疗方法需要进一步明确。

病例报告

我们报告了两例50多岁女性反复尿潴留并通过留置导尿管治疗的病例。第一例患者58岁,在五个月内下尿路症状逐渐加重,需要使用导尿管两个月。第二例患者50岁,持续存在排尿困难,之前的导尿试验失败。两位患者均无外伤、盆腔手术史或严重合并症。膀胱镜检查显示膀胱颈梗阻,逼尿肌中度小梁化。对膀胱颈进行了环形经尿道切除术(TURBN)。术后,两位患者均有明显改善,尿流率显示最大尿流率分别为10.7 mL/s和9.4 mL/s,残余尿量最少。未观察到尿失禁或其他并发症。

讨论

由于表现不具特异性,女性PBNO的诊断不足。其病理生理学涉及结构异常和潜在的神经源性因素。在我们的病例中,TURBN有效地改善了排尿功能,突出了其对保守治疗无反应患者的作用。然而,关于长期结局和风险的数据,如压力性尿失禁,仍然有限。

结论

TURBN是治疗女性PBNO的一种有前景的方法,可缓解症状并改善排尿功能。需要继续开展研究以完善技术并制定基于证据的指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b9/11755060/ef8d38befb7e/gr1.jpg

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