Chen Jiahao, Zhang Ren, Guo Sirui, Pan Ying, Nezamzadeh-Ejhieh Alireza, Lan Qian
The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523700, China; School of Pharmacy, Guangdong Medical University, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials, Dongguan, 523808, China.
School of Pharmacy, Guangdong Medical University, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials, Dongguan, 523808, China.
Talanta. 2025 May 1;286:127498. doi: 10.1016/j.talanta.2024.127498. Epub 2024 Dec 30.
This research presents a systematic review of the application of metal-organic frameworks (MOFs) to detect volatile organic compounds (VOCs). VOCs, compounds with high vapor pressure at ambient temperature and normal pressure, are widely present in a variety of industrial and living environments. VOCs are not only hazardous to the environment but also have a severe impact on human health. Therefore, an excellent research interest is developing efficient and sensitive detection technologies for VOCs. In this article, we first introduce the definition and classification of VOCs and their sources and discuss the environmental and health hazards of VOCs. Then, the discussion focuses on various sensors based on MOFs, including electrochemical sensors, fluorescence sensors, colorimetric sensors, and surface-enhanced Raman spectroscopy (SERS) sensors. In electrochemical detection, MOFs, as sensing materials, exhibit good detection performance due to their ultra-large surface area and highly adjustable pore size structure. In fluorescence detection, MOFs achieve high sensitivity and selective detection of VOCs under their unique optical properties. Colorimetric sensors, on the other hand, achieve the detection of VOCs through color change, which has the advantages of low cost and easy operation. In contrast, SERS sensors utilize the high surface area of MOFs and specific Raman enhancement effect to achieve ultra-high sensitivity detection of VOCs, which is especially suitable for trace analysis. Immediately after that, we describe the research progress of various sensors for VOCs detection and analyze their detection mechanisms and application prospects. Finally, the MOFs-based VOCs detection technology is summarized, and the current challenges and future development directions are pointed out.
本研究对金属有机框架（MOFs）在检测挥发性有机化合物（VOCs）中的应用进行了系统综述。VOCs是在环境温度和常压下具有高蒸气压的化合物，广泛存在于各种工业和生活环境中。VOCs不仅对环境有害，而且对人类健康有严重影响。因此，开发高效、灵敏的VOCs检测技术成为一个备受关注的研究领域。在本文中，我们首先介绍了VOCs的定义、分类及其来源，并讨论了VOCs对环境和健康的危害。然后，重点讨论了基于MOFs的各种传感器，包括电化学传感器、荧光传感器、比色传感器和表面增强拉曼光谱（SERS）传感器。在电化学检测中，MOFs作为传感材料，由于其超大的表面积和高度可调节的孔径结构，表现出良好的检测性能。在荧光检测中，MOFs凭借其独特的光学性质实现了对VOCs的高灵敏度和选择性检测。另一方面，比色传感器通过颜色变化实现对VOCs的检测，具有成本低、操作简便的优点。相比之下，SERS传感器利用MOFs的高表面积和特定的拉曼增强效应实现对VOCs的超高灵敏度检测，特别适用于痕量分析。紧接着，我们描述了用于VOCs检测的各种传感器的研究进展，并分析了它们的检测机制和应用前景。最后，总结了基于MOFs的VOCs检测技术，并指出了当前面临的挑战和未来的发展方向。
