Chromatin hubs drive key regulatory networks in leukemia.

作者信息

Swaroop Alok, Yue Feng

机构信息

Division of Hematology and Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA.

Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA.

出版信息

Mol Cell. 2025 Jan 2;85(1):1-2. doi: 10.1016/j.molcel.2024.12.011.

DOI:10.1016/j.molcel.2024.12.011

PMID:39753104

Abstract

In this issue of Molecular Cell, Gambi, Boccalatte, Hernaez, et al. apply multiomics followed by genetic engineering to define then characterize epigenetic hubs that regulate processes crucial for T-ALL and use this insight to offer new avenues for therapeutic targeting.

摘要