β乳头瘤病毒：在皮肤癌免疫中从敌人变为朋友
Beta papillomaviruses: From foe to friend in skin cancer immunity.
作者信息
Lebrusant-Fernandez Marta, Reading James L
机构信息
Pre-Cancer Immunology Laboratory, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK; Cancer Research UK Lung Cancer Centre of Excellence.
Pre-Cancer Immunology Laboratory, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK; Cancer Research UK Lung Cancer Centre of Excellence.
出版信息
Cancer Cell. 2025 Jan 13;43(1):6-7. doi: 10.1016/j.ccell.2024.12.005. Epub 2025 Jan 2.
In this issue of Cancer Cell, Son et al. highlight an unexpected role for skin β-papillomaviruses in the protection against skin carcinogenesis. T cell immunity to skin papillomaviruses blocks the expansion of p53 mutant clones in ultraviolet (UV) radiation-damaged skin, preventing the development of skin cancer.
在本期《癌细胞》杂志中，孙等人强调了皮肤β乳头瘤病毒在预防皮肤癌发生中出人意料的作用。针对皮肤乳头瘤病毒的T细胞免疫可阻止p53突变克隆在紫外线（UV）辐射损伤皮肤中的扩增，从而预防皮肤癌的发生。
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