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神经自发荧光与人工智能组织识别软件引导下的甲状腺手术

Thyroid surgery under nerve auto-fluorescence & artificial intelligence tissue identification software guidance.

作者信息

Dip Fernando, Aleman Rene, Rancati Alberto, Eiben Gustavo, Rosenthal Raul J, Sinagra Diego

机构信息

Department of General Surgery, Sanatorio Otamendi & Miroli (Otamendi & Miroli Hospital), University of Buenos Aires, Buenos Aires, Argentina.

出版信息

Langenbecks Arch Surg. 2025 Jan 4;410(1):23. doi: 10.1007/s00423-024-03597-1.

DOI:10.1007/s00423-024-03597-1
PMID:39753743
Abstract

Thyroid cancer is a common malignancy that requires comprehensive clinical evaluation prior to adequate surgical management. Over the last three decades thyroid surgery has tripled and is considered one of the most commonly performed procedures in general surgery. These procedures are associated with potential postoperative complications with significant deterioration in the patient's quality of life. While the current rates of recurrent laryngeal nerve injury following thyroidectomy have decreased secondary to intraoperative neuromonitoring, thyroid surgery remains the leading cause of iatrogenic injury. The authors herein present a case of a thyroid nodule with cervical lymph node involvement undergoing total thyroidectomy guided by near-ultraviolet (NUV) imaging nerve auto-fluorescent technology to visualize, identify and protect vital structures.

摘要

甲状腺癌是一种常见的恶性肿瘤,在进行充分的手术治疗之前需要进行全面的临床评估。在过去三十年中,甲状腺手术量增加了两倍,被认为是普通外科中最常进行的手术之一。这些手术可能会引发术后并发症,严重降低患者的生活质量。虽然由于术中神经监测,目前甲状腺切除术后喉返神经损伤的发生率有所下降,但甲状腺手术仍然是医源性损伤的主要原因。本文作者介绍了一例甲状腺结节伴颈部淋巴结受累的病例,该病例在近紫外(NUV)成像神经自发荧光技术的引导下进行了全甲状腺切除术,以可视化、识别和保护重要结构。

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本文引用的文献

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Use of fluorescence imaging and indocyanine green during thyroid and parathyroid surgery: Results of an intercontinental, multidisciplinary Delphi survey.甲状腺和甲状旁腺手术中荧光成像和吲哚菁绿的应用:一项洲际多学科德尔菲调查的结果。
Surgery. 2022 Dec;172(6S):S6-S13. doi: 10.1016/j.surg.2022.09.004.
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Nerve autofluorescence in near-ultraviolet light markedly enhances nerve visualization in vivo.近紫外光下的神经自发荧光显著增强了体内神经的可视化。
Surg Endosc. 2022 Mar;36(3):1999-2005. doi: 10.1007/s00464-021-08484-0. Epub 2021 Apr 9.
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Nerve spectroscopy: understanding peripheral nerve autofluorescence through photodynamics.
神经光谱学:通过光动力学理解周围神经自发荧光
Surg Endosc. 2021 Dec;35(12):7104-7111. doi: 10.1007/s00464-020-08227-7. Epub 2021 Mar 29.
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Energy vessel sealant devices are associated with decreased risk of neck hematoma after thyroid surgery.能量容器密封装置与甲状腺手术后颈部血肿风险降低有关。
Updates Surg. 2020 Dec;72(4):1135-1141. doi: 10.1007/s13304-020-00776-9. Epub 2020 Apr 24.
5
Randomized Controlled Trial Comparing White Light with Near-Infrared Autofluorescence for Parathyroid Gland Identification During Total Thyroidectomy.随机对照试验比较白光与近红外自体荧光在甲状腺全切除术中甲状旁腺识别中的应用。
J Am Coll Surg. 2019 May;228(5):744-751. doi: 10.1016/j.jamcollsurg.2018.12.044. Epub 2019 Jan 31.
6
International neuromonitoring study group guidelines 2018: Part II: Optimal recurrent laryngeal nerve management for invasive thyroid cancer-incorporation of surgical, laryngeal, and neural electrophysiologic data.2018年国际神经监测研究组指南:第二部分:侵袭性甲状腺癌的喉返神经最佳管理——纳入外科、喉部和神经电生理数据
Laryngoscope. 2018 Oct;128 Suppl 3:S18-S27. doi: 10.1002/lary.27360. Epub 2018 Oct 6.
7
International neural monitoring study group guideline 2018 part I: Staging bilateral thyroid surgery with monitoring loss of signal.国际神经监测研究组2018年指南第一部分:通过监测信号丢失进行双侧甲状腺手术分期
Laryngoscope. 2018 Oct;128 Suppl 3:S1-S17. doi: 10.1002/lary.27359. Epub 2018 Oct 5.
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Randomized clinical trial of intraoperative parathyroid gland angiography with indocyanine green fluorescence predicting parathyroid function after thyroid surgery.应用吲哚菁绿荧光术中甲状旁腺血管造影预测甲状腺手术后甲状旁腺功能的随机临床试验。
Br J Surg. 2018 Mar;105(4):350-357. doi: 10.1002/bjs.10783. Epub 2018 Feb 6.
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Increased identification of parathyroid glands using near infrared light during thyroid and parathyroid surgery.在甲状腺和甲状旁腺手术中使用近红外光增加甲状旁腺的识别。
Surg Endosc. 2017 Sep;31(9):3737-3742. doi: 10.1007/s00464-017-5424-1. Epub 2017 Mar 31.
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Cutting Edge in Thyroid Surgery: Autofluorescence of Parathyroid Glands.甲状腺手术前沿:甲状旁腺的自体荧光
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