福克斯洞察：帕金森病早期最恼人的症状
Fox Insight: Most Bothersome Symptoms in Early-Stage Parkinson's Disease.
作者信息
Lerner Aaron, Mammen Jennifer R, Tyo Mirinda, Auinger Peggy, Al-Rubayie Raunak, Xiao Yuge, Marras Connie, Adams Jamie L
机构信息
University of Rochester Medical Center, Center for Health + Technology (CHeT), Rochester, New York, USA.
College of Nursing and Health Sciences, University of Massachusetts Dartmouth, North Dartmouth, Massachusetts, USA.
出版信息
Mov Disord Clin Pract. 2025 Apr;12(4):510-515. doi: 10.1002/mdc3.14321. Epub 2025 Jan 3.
BACKGROUND
Limited evidence exists regarding the meaningfulness of symptoms experienced in early Parkinson's disease (PD).
OBJECTIVES
To identify the most bothersome symptoms experienced by people with early PD, leveraging data from the Parkinson's Disease Patient Report of Problems (PD-PROP) questionnaire within the Fox Insight Study.
METHODS
Individuals with a self-reported diagnosis of PD completed the PD-PROP questionnaire, reporting up to five most bothersome symptoms. Symptom types and frequencies were derived through a combination of human expertise and machine learning.
RESULTS
Participants (N = 8536) were 0.9 years since diagnosis, predominantly white (96%), male (53.3%), and with an average age of 64.6 years. Top most bothersome motor symptoms were tremor (55.9%) and gait issues (36.7%). Top most bothersome non-motor symptoms were pain/discomfort (33.1%) and physical fatigue (27.5%).
CONCLUSIONS
This study underscores the complexity of early PD symptomatology. Future consideration of diverse patient experiences is needed to improve therapeutic and outcome measurement strategies.
背景
关于早期帕金森病（PD）患者所经历症状的意义，现有证据有限。
目的
利用福克斯洞察研究中帕金森病患者问题报告（PD-PROP）问卷的数据，确定早期PD患者最困扰的症状。
方法
自我报告诊断为PD的个体完成PD-PROP问卷，报告最多五种最困扰的症状。症状类型和频率通过人工专业知识和机器学习相结合得出。
结果
参与者（N = 8536）自诊断以来平均0.9年，主要为白人（96%），男性（53.3%），平均年龄64.6岁。最困扰的运动症状是震颤（55.9%）和步态问题（36.7%）。最困扰的非运动症状是疼痛/不适（33.1%）和身体疲劳（27.5%）。
结论
本研究强调了早期PD症状学的复杂性。未来需要考虑不同患者的经历，以改进治疗和结果测量策略。
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