从发光蘑菇中分离出的共轭长链脂肪酸的驱虫潜力
Anthelmintic Potential of Conjugated Long-Chain Fatty Acids Isolated from the Bioluminescent Mushroom .
作者信息
Oliveira Maria D A, Dos S Andrade Teresinha de Jesus A, Junior Joaquim S C, Lima Nerilson Marques, Machado Hugo G, Tabudravu Jioji N, Pinto Francisco das Chagas L, Fukui-Silva Lucas, Amaro Monique C, de Moraes Josué, Silva Dulce Helena S, Citó Antônia Maria das Graças L, Feitosa Chistiane Mendes
机构信息
Department of Chemistry, Federal University of Piaui, Campus Ministro Petrônio Portela, Teresina, PI 64049-550, Brazil.
Nucleus of Applied Research to Sciences-NIAC, Federal Institute of Education, Science and Technology of Maranhao-IFMA, Presidente Dutra (Maranhao), Timon, Maranhao 65635-468, Brazil.
出版信息
J Nat Prod. 2025 Feb 28;88(2):255-261. doi: 10.1021/acs.jnatprod.4c00546. Epub 2025 Jan 4.
With praziquantel being the sole available drug for schistosomiasis, identifying novel anthelmintic agents is imperative. A chemical investigation of the fruiting body of the bioluminescent mushroom Berk. resulted in the isolation of new conjugated long-chain fatty acids (8,10,12,13)-12,13-dihydroxy-7-oxo-octadeca-8,10-dienoic acid () and (7,8,9,11)-7,8-dihydroxy-13-oxo-octadeca-9,11-dienoic acid () and three previously described compounds, (7,8,9)-7,8-dihydroxyoctadec-9-enoic acid (), (2)-dec-2-ene-1,10-dioic acid (), and a ketolactone marasmeno-1,15-dione (). Their planar structures were elucidated based on 1D and 2D NMR and MS/MS spectroscopic analyses. Compound displayed significant antiparasitic activity against (EC < 10 μM). No toxicity was observed in mammalian cells or .
由于吡喹酮是目前唯一可用于治疗血吸虫病的药物，因此鉴定新型驱虫剂势在必行。对发光蘑菇伯克氏菌子实体进行化学研究，分离出了新的共轭长链脂肪酸（8,10,12,13）-12,13-二羟基-7-氧代十八碳-8,10-二烯酸（）和（7,8,9,11）-7,8-二羟基-13-氧代十八碳-9,11-二烯酸（）以及三种先前已描述的化合物，（7,8,9）-7,8-二羟基十八碳-9-烯酸（）、（2）-癸-2-烯-1,10-二酸（）和一种酮内酯马拉斯莫-1,15-二酮（）。基于一维和二维核磁共振以及串联质谱光谱分析阐明了它们的平面结构。化合物对（疟原虫？此处原文缺失具体寄生虫名称）表现出显著的抗寄生虫活性（半数有效浓度<10 μM）。在哺乳动物细胞或（此处原文缺失具体内容）中未观察到毒性。
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