Hasegawa Tatsuya, Ishibashi Mayumi, Takata Takanobu, Takano Fumihide, Ohta Tomihisa
Department of Pharmacognosy and Chemistry of Natural Products, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
Chem Pharm Bull (Tokyo). 2007 Dec;55(12):1748-9. doi: 10.1248/cpb.55.1748.
The new conjugated ketonic fatty acid, porrigenic acid (1), was isolated as a cytotoxic constituent of Pleurocybella porrigens. The structure of 1 was elucidated using spectroscopic methods including 1D and 2D NMR and MS. The absolute stereochemistry of 1 was determined by application of the exciton chirality method. Compound 1 exhibited cytotoxic activity against myeloma THP-1 cells, but did not show any significant toxicity against B16F1 melanoma. This is the first report of the isolation and structural elucidation of the new cytotoxic constituent porrigenic acid (1) from the edible mushroom P. porrigens.
新的共轭酮脂肪酸——致孔酸（1），是从长根金钱菌中分离得到的一种细胞毒性成分。通过包括一维和二维核磁共振以及质谱在内的光谱方法阐明了1的结构。1的绝对立体化学通过激子手性方法确定。化合物1对骨髓瘤THP - 1细胞表现出细胞毒性活性，但对B16F1黑色素瘤未显示出任何显著毒性。这是首次从可食用蘑菇长根金钱菌中分离并阐明新的细胞毒性成分致孔酸（1）的结构的报告。
