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Single-cell multi-omics reveals tumor microenvironment factors underlying poor immunotherapy responses in ALK-positive lung cancer.

作者信息

Baek Seungbyn, Sung Euijeong, Kim Gamin, Hong Min Hee, Lee Chang Young, Shim Hyo Sup, Park Seong Yong, Kim Hye Ryun, Lee Insuk

机构信息

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.

Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.

出版信息

Cancer Commun (Lond). 2025 Apr;45(4):422-427. doi: 10.1002/cac2.12658. Epub 2025 Jan 4.

DOI:10.1002/cac2.12658
PMID:39754710
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11999889/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/774a/11999889/069011449307/CAC2-45-422-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/774a/11999889/069011449307/CAC2-45-422-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/774a/11999889/069011449307/CAC2-45-422-g001.jpg

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2
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells.BATF 和 IRF4 合作抵抗肿瘤浸润 CAR T 细胞耗竭。
Nat Immunol. 2021 Aug;22(8):983-995. doi: 10.1038/s41590-021-00964-8. Epub 2021 Jul 19.
3
The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation.
转录因子 ETS1 是人类 NK 细胞发育和终末分化的重要调节因子。
Blood. 2020 Jul 16;136(3):288-298. doi: 10.1182/blood.2020005204.
4
Molecular principles of metastasis: a hallmark of cancer revisited.转移的分子原理：重新审视癌症的一个标志
Signal Transduct Target Ther. 2020 Mar 12;5(1):28. doi: 10.1038/s41392-020-0134-x.
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The interplay between innate and adaptive immunity in cancer shapes the productivity of cancer immunosurveillance.先天免疫和适应性免疫在癌症中的相互作用塑造了癌症免疫监视的效率。
J Leukoc Biol. 2020 Jul;108(1):363-376. doi: 10.1002/JLB.3MIR0320-475R. Epub 2020 Apr 9.
6
B cells and tertiary lymphoid structures promote immunotherapy response.B 细胞和三级淋巴结构促进免疫治疗反应。
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