Allsop T F, Pauli J V
Res Vet Sci. 1985 Jan;38(1):61-4.
Samples of ventricular and lumbar cerebrospinal fluid (CSF) were taken at intervals from six lactating dairy cows, made hypomagnesaemic by feeding a magnesium-deficient diet. Initially the ventricular CSF had a higher magnesium concentration than lumbar CSF but as the cows became hypomagnesaemic the magnesium concentration in ventricular CSF decreased more rapidly than that in lumbar CSF. Tetany occurred when the concentration of magnesium in ventricular CSF fell below about 0.5 mmol litre-1. Intravenous infusion of magnesium into two hypomagnesaemic cows increased the concentration of magnesium in ventricular CSF before there was any change in the lumbar CSF. Newly formed CSF from the ventricles appeared to be more sensitive to changes in the concentration of magnesium in plasma than lumbar CSF which equilibrates with the diffusible magnesium of the central nervous system.
从六头泌乳期奶牛身上定期采集心室和腰椎脑脊液（CSF）样本，这些奶牛通过喂食缺镁日粮而导致低镁血症。最初，心室脑脊液中的镁浓度高于腰椎脑脊液，但随着奶牛出现低镁血症，心室脑脊液中的镁浓度下降速度比腰椎脑脊液更快。当心室脑脊液中的镁浓度降至约0.5毫摩尔/升以下时，就会发生抽搐。对两头低镁血症奶牛进行静脉输注镁后，在腰椎脑脊液出现任何变化之前，心室脑脊液中的镁浓度就升高了。与与中枢神经系统可扩散镁平衡的腰椎脑脊液相比，心室新生成的脑脊液似乎对血浆中镁浓度的变化更敏感。
