解码蛋白质甲基化组：鉴定、验证及功能见解
Decoding the protein methylome: Identification, validation, and functional insights.
作者信息
Meng Ying, Huang Rong
机构信息
Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute for Drug Discovery, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States.
Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute for Drug Discovery, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States.
出版信息
Bioorg Med Chem. 2025 Feb 1;118:118056. doi: 10.1016/j.bmc.2024.118056. Epub 2024 Dec 28.
Protein methylation regulates diverse cellular processes including gene expression and DNA repair. This review discusses the methods of identifying and validating substrates for protein methyltransferases (MTases), as well as the biological roles of methylation. Meanwhile, we outline continued efforts necessary to fully map MTase-substrate pairs and uncover the complex regulatory roles of protein methylation in cellular function.
蛋白质甲基化调节多种细胞过程，包括基因表达和DNA修复。本综述讨论了鉴定和验证蛋白质甲基转移酶（MTases）底物的方法，以及甲基化的生物学作用。同时，我们概述了全面绘制MTase-底物对并揭示蛋白质甲基化在细胞功能中的复杂调节作用所需的持续努力。
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