Huang Guangqing, Yang Wenzi, Zhao Xu, Bai Yong, Jiang Xing, Liu Jie
Emergency and Critical Care Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Reproductive Medicine Centre, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
J Cardiothorac Surg. 2025 Jan 4;20(1):16. doi: 10.1186/s13019-024-03274-w.
We sought to investigate the expression of MALAT1, plasma brain natriuretic peptide, and Tei index in sepsis-induced myocardial injury.
The current retrospective analysis focused on 146 sepsis patients admitted to our hospital from February 2021 to March 2023. Based on the presence or absence of myocardial injury, the patients were divided into two groups: the sepsis group (n = 80) and the sepsis-induced myocardial injury group (n = 66). Based on the 28-day mortality status of the patients, they were also divided into a survival group of 143 cases and a death group of 3 cases. The study compared the levels of MALAT1, plasma brain natriuretic peptide, and Tei index between the sepsis group and sepsis-induced myocardial injury group, as well as the comparison of two sets of ultrasound indicators. Univariate logistic regression analysis was performed to identify the influencing factors of sepsis-induced myocardial injury, followed by multivariate logistic regression analysis to identify the influencing factors of such condition. MALAT1, plasma brain natriuretic peptide and cardiac Tei index between the survival and death groups were compared and Pearson correlation analysis was conduct to assess their correlations.
In terms of general information, there were no significant differences in gender, age, BMI, mean arterial pressure, systolic pressure, diastolic pressure, respiratory rate, oxygenation index, basic diseases and infection site between the two groups (P > 0.05). However, significant differences were observed in heart rate, SOFA score, and APACHE II score between the two groups (P < 0.05). The levels of MALAT1, plasma brain natriuretic peptide, and Tei index in the sepsis-induced myocardial injury group were significantly higher than those in the sepsis group (P < 0.05). Furthermore, the sepsis-induced myocardial injury group exhibited lower left ventricular end-diastolic diameter and left ventricular end-systolic diameter compared to the sepsis group, along with higher levels of E, E/e', and e', showing significant differences (P < 0.05). The independent variables considered in the analysis included general data, ultrasound indicators with significant differences, as well as MALAT1, plasma brain natriuretic peptide, and Tei index. The dependent variable was sepsis-induced myocardial injury, and univariate logistic regression analysis identified E, E/e', e', MALAT1, plasma brain natriuretic peptide, and Tei index as influencing factors of sepsis-induced myocardial injury. Subsequently, a multivariate logistic regression analysis was conducted with the independent variables set as E, E/e', e', MALAT1, plasma brain natriuretic peptide, and Tei index, and the dependent variable as sepsis-induced myocardial injury. The results indicated that MALAT1, plasma brain natriuretic peptide, and Tei index were influencing factors of sepsis-induced myocardial injury. The levels of MALAT1, plasma brain natriuretic peptide and cardiac Tei index in the death group were significantly higher than those in the survival group (P < 0.05). The Pearson correlation analysis showed that MALAT1, plasma brain natriuretic peptide and cardiac Tei index were correlated with the prognosis of patients with sepsis-induced myocardial injury (P < 0.05).
We demonstrated high expression levels of MALAT1, plasma brain natriuretic peptide, and Tei index in patients with sepsis-induced myocardial injury. Ultrasound indicators can effectively contribute to the diagnosis of sepsis-induced myocardial injury. Moreover, MALAT1, plasma brain natriuretic peptide, and Tei index have been identified as influencing factors of sepsis-induced myocardial injury.
我们旨在研究长链非编码RNA MALAT1、血浆脑钠肽及Tei指数在脓毒症诱导的心肌损伤中的表达情况。
本回顾性分析聚焦于2021年2月至2023年3月我院收治的146例脓毒症患者。根据是否存在心肌损伤，将患者分为两组：脓毒症组（n = 80）和脓毒症诱导的心肌损伤组（n = 66）。根据患者28天的死亡情况，又将其分为143例生存组和3例死亡组。本研究比较了脓毒症组与脓毒症诱导的心肌损伤组之间MALAT1、血浆脑钠肽及Tei指数水平，以及两组超声指标的比较。进行单因素逻辑回归分析以确定脓毒症诱导的心肌损伤的影响因素，随后进行多因素逻辑回归分析以确定该病症的影响因素。比较了生存组和死亡组之间的MALAT1、血浆脑钠肽及心脏Tei指数，并进行Pearson相关性分析以评估它们之间的相关性。
在一般信息方面，两组在性别、年龄、体重指数、平均动脉压、收缩压、舒张压、呼吸频率、氧合指数、基础疾病及感染部位方面无显著差异（P > 0.05）。然而，两组在心率、序贯器官衰竭评估（SOFA）评分及急性生理与慢性健康状况评分系统II（APACHE II）评分方面存在显著差异（P < 0.05）。脓毒症诱导的心肌损伤组中MALAT1、血浆脑钠肽及Tei指数水平显著高于脓毒症组（P < 0.05）。此外，与脓毒症组相比，脓毒症诱导的心肌损伤组左心室舒张末期内径和左心室收缩末期内径较低，而E、E/e'和e'水平较高，差异有统计学意义（P < 0.05）。分析中考虑的自变量包括一般数据、有显著差异的超声指标，以及MALAT1、血浆脑钠肽和Tei指数。因变量为脓毒症诱导的心肌损伤，单因素逻辑回归分析确定E、E/e'、e'、MALAT1、血浆脑钠肽和Tei指数为脓毒症诱导的心肌损伤的影响因素。随后，将自变量设定为E、E/e'、e'、MALAT1、血浆脑钠肽和Tei指数，因变量为脓毒症诱导的心肌损伤，进行多因素逻辑回归分析。结果表明，MALAT1、血浆脑钠肽和Tei指数是脓毒症诱导的心肌损伤的影响因素。死亡组中MALAT1、血浆脑钠肽及心脏Tei指数水平显著高于生存组（P < 0.05）。Pearson相关性分析表明，MALAT1、血浆脑钠肽及心脏Tei指数与脓毒症诱导的心肌损伤患者的预后相关（P < 0.05）。
我们证明了脓毒症诱导的心肌损伤患者中MALAT1、血浆脑钠肽及Tei指数表达水平较高。超声指标可有效辅助脓毒症诱导的心肌损伤的诊断。此外，MALAT1、血浆脑钠肽及Tei指数已被确定为脓毒症诱导的心肌损伤的影响因素。
