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再生障碍性贫血患者短期半固体骨髓培养中的人骨髓基质细胞

Human marrow stromal cells in short-term semi-solid bone marrow culture in aplastic anaemia.

作者信息

Reynolds M, McCann S R

出版信息

Scand J Haematol. 1985 Feb;34(2):101-10. doi: 10.1111/j.1600-0609.1985.tb02241.x.

DOI:10.1111/j.1600-0609.1985.tb02241.x
PMID:3975567
Abstract

A short-term methylcellulose technique was used to study the proliferation of marrow-derived stromal, erythroid and myeloid colonies from normal controls and from patients with aplastic anaemia. There was a significant reduction in all colony types in patients with aplastic anaemia when compared with normal controls. In 4 patients who achieved remission following treatment with ATG + oxymetholone or with oxymetholone alone there was a return to normal range of stromal colonies and also of CFU-E. There was no change in the numbers of BFU-E's and only a slight increase in the numbers of CFU-C's.

摘要

采用短期甲基纤维素技术研究正常对照者及再生障碍性贫血患者骨髓来源的基质细胞、红系和髓系集落的增殖情况。与正常对照者相比,再生障碍性贫血患者的所有集落类型均显著减少。4例接受抗胸腺细胞球蛋白(ATG)+羟甲烯龙治疗或仅接受羟甲烯龙治疗后获得缓解的患者,其基质细胞集落以及红细胞集落形成单位(CFU-E)恢复至正常范围。爆式红系集落形成单位(BFU-E)数量无变化,集落形成单位 - 粒(CFU-C)数量仅略有增加。

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