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miR-101-3p和miR-431-5p作为类风湿性关节炎潜在诊断生物标志物的表达谱

Expression profiles of miR-101-3p and miR-431-5p as potential diagnostic biomarkers for rheumatoid arthritis.

作者信息

Sadaty Mohamed M, Mekhemer Salma M, Abdel-Ghany Shaimaa, El-Ansary Amira R, Mohamed Rana, Kamal Nashaat N, Sabit Hussein

机构信息

Department of Technology of Medical Laboratory, Faculty of Applied Health Science Technology, Misr University for Science and Technology, P. O. Box 77, Giza, Egypt.

Department of Environmental Biotechnology, College of Biotechnology, Misr University for Science and Technology, P. O. Box 77, Giza, Egypt.

出版信息

Sci Rep. 2025 Jan 4;15(1):776. doi: 10.1038/s41598-024-82339-1.

DOI:10.1038/s41598-024-82339-1
PMID:39755725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11700103/
Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation of the synovial joints, leading to cartilage and bone destruction. This study aimed to evaluate the diagnostic utility of specific microRNAs (miRNAs) as potential biomarkers for RA. The study was conducted on 60 patients with RA disease along with 20 control participants. Comprehensive analysis of patient data, encompassing serological, hematological, and biochemical markers, revealed significantly elevated levels of miR-99b-5p, miR-101-3p, and miR-431-5p in RA patients compared to healthy controls. Among these, miR-101-3p demonstrated the highest diagnostic accuracy, with an area under the curve (AUC) of 0.873. These findings contribute to a deeper understanding of RA pathogenesis and suggest that miR-101-3p may serve as a valuable biomarker for early disease detection and potentially improved patient management. Further research is warranted to elucidate the precise mechanisms underlying miRNA involvement in RA and to explore their potential as therapeutic targets.

摘要

类风湿性关节炎（RA）是一种慢性自身免疫性疾病，其特征是滑膜关节持续炎症，导致软骨和骨破坏。本研究旨在评估特定微小RNA（miRNA）作为RA潜在生物标志物的诊断效用。该研究对60例RA患者和20名对照参与者进行。对患者数据进行全面分析，包括血清学、血液学和生化标志物，结果显示与健康对照相比，RA患者中miR-99b-5p、miR-101-3p和miR-431-5p水平显著升高。其中，miR-101-3p表现出最高的诊断准确性，曲线下面积（AUC）为0.873。这些发现有助于更深入地了解RA发病机制，并表明miR-101-3p可能作为一种有价值的生物标志物用于早期疾病检测和潜在地改善患者管理。有必要进行进一步研究以阐明miRNA参与RA的精确机制，并探索它们作为治疗靶点的潜力。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361f/11700103/8adce9d2280c/41598_2024_82339_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361f/11700103/7de9d68ca5d0/41598_2024_82339_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361f/11700103/5c64b539416b/41598_2024_82339_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361f/11700103/bd631f212656/41598_2024_82339_Fig9_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361f/11700103/8aa889ec20da/41598_2024_82339_Fig11_HTML.jpg

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