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双侧胫后神经多发性神经鞘瘤——病例报告及文献复习

Multiple schwannomas of bilateral posterior tibial nerves - A case report and review of literature.

作者信息

Gomez Deshan Mario, Kottegoda Gayanga Jayapahan, Gunawardana Thanuka Sajith Panditha, Pirakash Pathmanesan, Attanayake Deepal

机构信息

Neurosurgical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.

Neurosurgical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.

出版信息

Int J Surg Case Rep. 2025 Jan;126:110833. doi: 10.1016/j.ijscr.2025.110833. Epub 2025 Jan 3.

Abstract

INTRODUCTION

Schwannoma is a type of slow growing benign nerve sheath tumor arising from Schwann cells. Peripherally, they are found in association with the ulnar, sciatic and posterior tibial nerves. Peripheral schwannomas, neurofibromas and malignant PNSTs are collectively grouped as peripheral nerve sheath tumors.

PRESENTATION OF CASE

We report a case of a 35-year-old male, without clinical features of NF2, presenting with 2 painful lumps around the ankle, and was incidentally found to have multiple lumps in both lower limbs. MR imaging, surgical excision and histology revealed multiple bilateral posterior tibial nerve schwannomas.

DISCUSSION

Schwannomas usually occur as a solitary mass or sometimes multiple. Multiple schwannomas are seen in association with type 2 neurofibromatosis and Schwannomatosis. Schwannomatosis is a separate clinical entity with considerable overlap both in phenotype and presentation with NF2 but that can be distinguished from NF2 based on clinical diagnostic criteria. Peripheral schwannoma is a differential diagnosis for painful lumps with positive Tinel's sign in close association to peripheral nerves, mainly posterior tibial, sciatic and ulnar nerve. Surgical excision can be safely performed with preservation of the nerve using meticulous technique.

CONCLUSION

Schwannomas of the posterior tibial nerve (PTN) and its medial and lateral plantar branch have been described as a cause of tarsal tunnel syndrome and foot pain. Although multiple reports of solitary PTN schwannomas exist, only 4 cases of multiple PTN schwannomas have been reported in literature, with no reports of cases involving bilateral PTN.

摘要

引言

施万细胞瘤是一种生长缓慢的良性神经鞘瘤,由施万细胞产生。在周围,它们与尺神经、坐骨神经和胫后神经相关。周围性施万细胞瘤、神经纤维瘤和恶性外周神经鞘膜瘤统称为周围神经鞘瘤。

病例介绍

我们报告一例35岁男性,无神经纤维瘤病2型(NF2)的临床特征,表现为踝关节周围有2个疼痛性肿块,偶然发现双下肢有多个肿块。磁共振成像、手术切除和组织学检查显示双侧多发胫后神经施万细胞瘤。

讨论

施万细胞瘤通常表现为单个肿块,有时也为多个。多发施万细胞瘤与2型神经纤维瘤病和施万细胞瘤病相关。施万细胞瘤病是一种独立的临床实体,在表型和表现上与NF2有相当大的重叠,但可根据临床诊断标准与NF2区分。周围性施万细胞瘤是与周围神经(主要是胫后神经、坐骨神经和尺神经)紧密相关且Tinel征阳性的疼痛性肿块的鉴别诊断。使用精细技术在保留神经的情况下可安全地进行手术切除。

结论

胫后神经(PTN)及其足底内侧和外侧分支的施万细胞瘤已被描述为跗管综合征和足部疼痛的原因。虽然有关于孤立性PTN施万细胞瘤的多篇报道,但文献中仅报道了4例多发PTN施万细胞瘤,尚无双侧PTN病例的报道。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff65/11757767/c69ed655ce20/gr1.jpg

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