Wentz W B
Semin Oncol. 1985 Mar;12(1 Suppl 1):23-7.
This paper details several studies of the effect of a single progestin, megestrol acetate, in patients with persistent endometrial hyperplasia and recurrent or persistent endometrial adenocarcinoma. Results of these studies indicate that megestrol acetate inhibits recurrence of adenomatous and atypical hyperplasia as well as adenocarcinoma in situ. These diseases when left untreated often progress to invasive adenocarcinoma. Additional studies presented here show that megestrol acetate is effective in the treatment of endometrial adenocarcinoma in inoperable patients and increases survival in patients with recurrent endometrial cancer.
本文详细介绍了关于单一孕激素醋酸甲地孕酮对持续性子宫内膜增生以及复发性或持续性子宫内膜腺癌患者影响的多项研究。这些研究结果表明，醋酸甲地孕酮可抑制腺瘤性和非典型增生以及原位腺癌的复发。这些疾病若不治疗，往往会发展为浸润性腺癌。本文展示的其他研究表明，醋酸甲地孕酮对无法手术的患者的子宫内膜腺癌治疗有效，并可提高复发性子宫内膜癌患者的生存率。
