Shou Minyu, Lin Qinzhe, Xu Ying, Zhu Ruiyan, Shi Min, Kai Guoyin
The Key Laboratory of Traditional Chinese Medicine Resources Innovation and Transformation in Zhejiang Province, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou 310053, China.
The Key Laboratory of Traditional Chinese Medicine Resources Innovation and Transformation in Zhejiang Province, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou 310053, China; College of Horticulture, Shenyang Agricultural University, Shenyang 110866, China.
Plant Sci. 2025 Mar;352:112384. doi: 10.1016/j.plantsci.2025.112384. Epub 2025 Jan 3.
Salvia miltiorrhiza Bunge, a well-known traditional Chinese herbal medicine, has been served as not only medicine for human ailments, but also health care products. As one of major bioactive ingredients, tanshinones are widely used to treat cardiovascular and cerebrovascular diseases, and also possess different pharmacological activities including anti-tumor, anti-inflammatory, anti-fibrotic and others. However, the content of tanshinones is relatively low in S. miltiorrhiza plants. Recently, multiple biotechnological strategies have been applied to improve tanshinone production. In this review, advances in bioactivities, biosynthesis pathway and regulation, transcriptional regulatory network, epigenetic modification and synthetic biology are summarized, and future perspectives are discussed, which will help develop high-quality S. miltiorrhiza resources.
丹参是一种著名的传统中药，不仅用作治疗人类疾病的药物，还用作保健品。作为主要生物活性成分之一，丹参酮被广泛用于治疗心脑血管疾病，还具有包括抗肿瘤、抗炎、抗纤维化等不同的药理活性。然而，丹参植物中丹参酮的含量相对较低。近年来，多种生物技术策略已被应用于提高丹参酮的产量。在这篇综述中，总结了丹参酮的生物活性、生物合成途径与调控、转录调控网络、表观遗传修饰和合成生物学等方面的研究进展，并讨论了未来的研究方向，这将有助于开发优质的丹参资源。
