Kwon John Y, Vera Renzo E, Fernandez-Zapico Martin E
Schulze Center for Novel Therapeutics, Division of Oncology Research, Rochester, MN 55901, USA.
Cell Signal. 2025 Mar;127:111584. doi: 10.1016/j.cellsig.2024.111584. Epub 2025 Jan 3.
The tumor microenvironment (TME) has been linked with the pathogenesis of pancreatic ductal adenocarcinoma (PDAC), the most common histological subtype of pancreatic cancer. A central component of the TME are cancer-associated fibroblasts (CAFs), which can either suppress or promote tumor growth in a context-dependent manner. In this review, we will discuss the multi-faceted roles of CAFs in tumor-stroma interactions influencing cancer initiation, progression and therapeutic response.
肿瘤微环境（TME）与胰腺癌最常见的组织学亚型——胰腺导管腺癌（PDAC）的发病机制相关。肿瘤微环境的一个核心组成部分是癌症相关成纤维细胞（CAFs），它们可以根据具体情况抑制或促进肿瘤生长。在这篇综述中，我们将讨论癌症相关成纤维细胞在影响癌症起始、进展和治疗反应的肿瘤-基质相互作用中的多方面作用。
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