Lee Dae-In, Kim Sunwon, Kang Dong Oh
Cardiovascular Center, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Cardiovascular Center, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Trends Cardiovasc Med. 2025 May;35(4):243-253. doi: 10.1016/j.tcm.2024.12.011. Epub 2025 Jan 3.
This review article explores the intricate relationship between alcohol consumption and cardiovascular health, underscoring on both clinical outcomes and underlying pathophysiological mechanisms. It examines the complex dose-response relationships for various cardiovascular disease (CVD) subtypes, including coronary heart disease, stroke, and atrial fibrillation, while categorizing pathophysiological mechanisms into three conceptual areas: primary initiating factors, secondary transmission pathways, and end-organ effects. Although mild-to-moderate alcohol consumption may confer some benefits for cardiovascular health and certain CVD subtypes, growing evidence highlights the importance of lifestyle modifications to reduce alcohol intake, particularly among heavy drinkers. This review provides a comprehensive overview of current knowledge, emphasizes the need for future research with robust methodologies, and advocates for incorporating updated scientific evidence into personalized approaches within international cardiovascular and national guidelines.
这篇综述文章探讨了饮酒与心血管健康之间的复杂关系，强调了临床结果和潜在病理生理机制两方面。它研究了各种心血管疾病（CVD）亚型的复杂剂量反应关系，包括冠心病、中风和心房颤动，同时将病理生理机制分为三个概念领域：主要起始因素、次要传播途径和终末器官效应。尽管轻度至中度饮酒可能对心血管健康和某些CVD亚型有一些益处，但越来越多的证据强调了改变生活方式以减少酒精摄入量的重要性，特别是在重度饮酒者中。这篇综述全面概述了当前的知识，强调了采用强有力方法进行未来研究的必要性，并主张将最新科学证据纳入国际心血管和国家指南中的个性化方法。
