Hosomi Ryota
Laboratory of Food and Nutritional Sciences, Faculty of Chemistry, Materials and Bioengineering, Kansai University.
J Oleo Sci. 2025;74(1):1-11. doi: 10.5650/jos.ess24253.
Omega-3 long-chain polyunsaturated fatty acids (PUFA) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are widely used as supplements and pharmaceuticals because of their beneficial effects on human health. Triacylglycerols (TAG) and glycerophospholipids (GPL) comprise the primary chemical structures of DHA/EPA in marine sources. Furthermore, DHA/EPA-enriched glycerophospholipids (DHA/EPA-GPL) and lysoglycerophospholipids (DHA/EPA-LysoGPL) consumed through food and supplements are more effective than TAG in promoting health, which may be attributed to a specific underlying mechanism. However, the specific effects of DHA/EPA bound to GPL structure have been still unclear. The aim of this review is to clarify the significance of the binding of DHA/EPA to GPL in promoting the health benefits of DHA/EPA-GPL and DHA/EPA-LysoGPL. Additionally, the potential use of fishery by-products as sources of DHA/EPA-GPL and DHA/EPA-LysoGPL has been discussed.
ω-3长链多不饱和脂肪酸（PUFA），如二十二碳六烯酸（DHA）和二十碳五烯酸（EPA），因其对人体健康有益而被广泛用作补充剂和药物。甘油三酯（TAG）和甘油磷脂（GPL）构成了海洋来源中DHA/EPA的主要化学结构。此外，通过食物和补充剂摄入的富含DHA/EPA的甘油磷脂（DHA/EPA-GPL）和溶血甘油磷脂（DHA/EPA-LysoGPL）在促进健康方面比TAG更有效，这可能归因于特定的潜在机制。然而，与GPL结构结合的DHA/EPA的具体作用仍不清楚。本综述的目的是阐明DHA/EPA与GPL结合在促进DHA/EPA-GPL和DHA/EPA-LysoGPL对健康有益作用方面的重要性。此外，还讨论了将渔业副产品用作DHA/EPA-GPL和DHA/EPA-LysoGPL来源的潜在用途。
